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• W2076579368 abstract "Overexposure of the skin to UV radiation has a variety of adverse effects on human health, including the development of skin cancers. There is a need to develop nutrition-based efficient chemopreventive strategies. The proanthocyanidins present in grape seeds (Vitis vinifera) have been shown to have some biological effects, including prevention of photocarcinogenesis. The present communication discusses the in vitro and in vivo studies of the possible protective effect of grape seed proanthocyanidins (GSPs) and the molecular mechanism for these effects. In SKH-1 hairless mice, dietary supplementation with GSPs is associated with a decrease of UVB-induced skin tumor development in terms of tumor incidence, tumor multiplicity, and a decrease in the malignant transformation of papillomas to carcinomas. It is suggested that the chemopreventive effects of dietary GSPs are mediated through the attenuation of UV-induced: (i) oxidative stress; (ii) activation of mitogen-activated protein kinases and nuclear factor-kappa B (NF-kappaB) signaling pathways; and (iii) immunosuppression through alterations in immunoregulatory cytokines. Collectively, these studies indicate protective potential of GSPs against experimental photocarcinogenesis in SKH-1 hairless mice, and the possible mechanisms of action of GSPs, and suggest that dietary GSPs could be useful in the attenuation of the adverse UV-induced health effects in human skin." @default.
• W2076579368 created "2016-06-24" @default.
• W2076579368 creator A5036743590 @default.
• W2076579368 date "2008-04-02" @default.
• W2076579368 modified "2023-10-18" @default.
• W2076579368 title "Grape seed proanthocyanidines and skin cancer prevention: Inhibition of oxidative stress and protection of immune system" @default.
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• W2076579368 doi "https://doi.org/10.1002/mnfr.200700198" @default.
• W2076579368 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2562900" @default.
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• W2076579368 hasPublicationYear "2008" @default.
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