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• W2076579909 abstract "Human myosin heavy chains are encoded by a multigene family consisting of at least 10 members. A gene-specific oligonucleotide has been used to isolate the human β myosin heavy chain gene from a group of twelve nonoverlapping genomic clones. We have shown that this gene (which is expressed in both cardiac and skeletal muscle) is located 3.6kb upstream of the a cardiac myosin gene. We find that DNA sequences located upstream of rat and human a cardiac myosin heavy chain genes are very homologous over a 300bp region. Analogous regions of two other myosin genes expressed in different muscles (cardiac and skeletal) show no such homology to each other. While a human skeletal muscle myosin heavy chain gene cluster is located on chromosome 17, we show that the β and α human cardiac myosin heavy chain genes are located on chromosome 14." @default.
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• W2076579909 date "1987-01-01" @default.
• W2076579909 modified "2023-10-16" @default.
• W2076579909 title "Human cardiac myosin heavy chain genes and their linkage in the genome" @default.
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• W2076579909 doi "https://doi.org/10.1093/nar/15.13.5443" @default.
• W2076579909 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/305971" @default.
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