FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076588929> ?p ?o ?g. }

• W2076588929 endingPage "e84451" @default.
• W2076588929 startingPage "e84451" @default.
• W2076588929 abstract "Mouse and rat skeletal muscles are capable of a regulatory volume increase (RVI) after they shrink (volume loss resultant from exposure to solutions of increased osmolarity) and that this RVI occurs mainly by a Na-K-Cl-Cotransporter (NKCC)-dependent mechanism. With high-intensity exercise, increased extracellular osmolarity is accompanied by large increases in extracellular [lactate⁻]. We hypothesized that large increases in [lactate⁻] and osmolarity augment the NKCC-dependent RVI response observed with a NaCl (or sucrose)-induced increase in osmolarity alone; a response that is dependent on lactate⁻ influx through monocarboxylate transporters (MCTs). Single mouse muscle fibres were isolated and visualized under light microscopy under varying osmolar conditions. When solution osmolarity was increased by adding NaLac by 30 or 60 mM, fibres lost significantly less volume and regained volume sooner compared to when NaCl was used. Phloretin (MCT1 inhibitor) accentuated the volume loss compared to both NaLac controls, supporting a role for MCT1 in the RVI response in the presence of elevated [lactate⁻]. Inhibition of MCT4 (with pCMBS) resulted in a volume loss, intermediate to that seen with phloretin and NaLac controls. Bumetanide (NKCC inhibitor), in combination with pCMBS, reduced the magnitude of volume loss, but volume recovery was complete. While combined phloretin-bumetanide also reduced the magnitude of the volume loss, it also largely abolished the cell volume recovery. In conclusion, RVI in skeletal muscle exposed to raised tonicity and [lactate⁻] is facilitated by inward flux of solute by NKCC- and MCT1-dependent mechanisms. This work demonstrates evidence of a RVI response in skeletal muscle that is facilitated by inward flux of solute by MCT-dependent mechanisms. These findings further expand our understanding of the capacities for skeletal muscle to volume regulate, particularly in instances of raised tonicity and lactate⁻ concentrations, as occurs with high intensity exercise." @default.
• W2076588929 created "2016-06-24" @default.
• W2076588929 creator A5039146557 @default.
• W2076588929 creator A5039812838 @default.
• W2076588929 creator A5043888089 @default.
• W2076588929 date "2013-12-23" @default.
• W2076588929 modified "2023-10-18" @default.
• W2076588929 title "Inward Flux of Lactate- through Monocarboxylate Transporters Contributes to Regulatory Volume Increase in Mouse Muscle Fibres" @default.
• W2076588929 cites W1546474298 @default.
• W2076588929 cites W1897390225 @default.
• W2076588929 cites W1908454203 @default.
• W2076588929 cites W1974269652 @default.
• W2076588929 cites W1974541555 @default.
• W2076588929 cites W1975933806 @default.
• W2076588929 cites W1982780568 @default.
• W2076588929 cites W1985075574 @default.
• W2076588929 cites W2001176512 @default.
• W2076588929 cites W2005312758 @default.
• W2076588929 cites W2013441023 @default.
• W2076588929 cites W2027272650 @default.
• W2076588929 cites W2032515653 @default.
• W2076588929 cites W2046064264 @default.
• W2076588929 cites W2052415225 @default.
• W2076588929 cites W2053937058 @default.
• W2076588929 cites W2054630465 @default.
• W2076588929 cites W2062056760 @default.
• W2076588929 cites W2066841256 @default.
• W2076588929 cites W2069051826 @default.
• W2076588929 cites W2079168239 @default.
• W2076588929 cites W2082643182 @default.
• W2076588929 cites W2084377042 @default.
• W2076588929 cites W2099334940 @default.
• W2076588929 cites W2102506613 @default.
• W2076588929 cites W2109501538 @default.
• W2076588929 cites W2116618150 @default.
• W2076588929 cites W2118320100 @default.
• W2076588929 cites W2119192481 @default.
• W2076588929 cites W2121873746 @default.
• W2076588929 cites W2122334450 @default.
• W2076588929 cites W2125698173 @default.
• W2076588929 cites W2127685770 @default.
• W2076588929 cites W2136791651 @default.
• W2076588929 cites W2154404271 @default.
• W2076588929 cites W2167622666 @default.
• W2076588929 cites W2170994089 @default.
• W2076588929 cites W2188816813 @default.
• W2076588929 cites W2224021986 @default.
• W2076588929 cites W2259277792 @default.
• W2076588929 cites W4241459372 @default.
• W2076588929 cites W55072562 @default.
• W2076588929 doi "https://doi.org/10.1371/journal.pone.0084451" @default.
• W2076588929 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3871844" @default.
• W2076588929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24376811" @default.
• W2076588929 hasPublicationYear "2013" @default.
• W2076588929 type Work @default.
• W2076588929 sameAs 2076588929 @default.
• W2076588929 citedByCount "7" @default.
• W2076588929 countsByYear W20765889292016 @default.
• W2076588929 countsByYear W20765889292017 @default.
• W2076588929 countsByYear W20765889292018 @default.
• W2076588929 countsByYear W20765889292021 @default.
• W2076588929 countsByYear W20765889292022 @default.
• W2076588929 crossrefType "journal-article" @default.
• W2076588929 hasAuthorship W2076588929A5039146557 @default.
• W2076588929 hasAuthorship W2076588929A5039812838 @default.
• W2076588929 hasAuthorship W2076588929A5043888089 @default.
• W2076588929 hasBestOaLocation W20765889291 @default.
• W2076588929 hasConcept C104317684 @default.
• W2076588929 hasConcept C120405084 @default.
• W2076588929 hasConcept C121332964 @default.
• W2076588929 hasConcept C12554922 @default.
• W2076588929 hasConcept C126322002 @default.
• W2076588929 hasConcept C129900496 @default.
• W2076588929 hasConcept C134018914 @default.
• W2076588929 hasConcept C149011108 @default.
• W2076588929 hasConcept C178790620 @default.
• W2076588929 hasConcept C185592680 @default.
• W2076588929 hasConcept C188053792 @default.
• W2076588929 hasConcept C20556612 @default.
• W2076588929 hasConcept C2113261 @default.
• W2076588929 hasConcept C2778212192 @default.
• W2076588929 hasConcept C2778423325 @default.
• W2076588929 hasConcept C2779959927 @default.
• W2076588929 hasConcept C28406088 @default.
• W2076588929 hasConcept C537181965 @default.
• W2076588929 hasConcept C55493867 @default.
• W2076588929 hasConcept C62520636 @default.
• W2076588929 hasConcept C71924100 @default.
• W2076588929 hasConcept C86803240 @default.
• W2076588929 hasConceptScore W2076588929C104317684 @default.
• W2076588929 hasConceptScore W2076588929C120405084 @default.
• W2076588929 hasConceptScore W2076588929C121332964 @default.
• W2076588929 hasConceptScore W2076588929C12554922 @default.
• W2076588929 hasConceptScore W2076588929C126322002 @default.
• W2076588929 hasConceptScore W2076588929C129900496 @default.
• W2076588929 hasConceptScore W2076588929C134018914 @default.
• W2076588929 hasConceptScore W2076588929C149011108 @default.
• W2076588929 hasConceptScore W2076588929C178790620 @default.

• next