Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076596341> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2076596341 endingPage "146" @default.
- W2076596341 startingPage "142" @default.
- W2076596341 abstract "A potentially critical limiting factor in the use of free-electron lasers to determine the structure of organic molecules is the damage the procedure may cause. A model based on coherence theory and quantum electrodynamics suggests that it should be possible to reconstruct a molecule’s structure from the X-ray data obtained as it undergoes damage. The challenges involved in determining the structures of molecules to atomic resolution in non-crystalline samples using X-ray free-electron laser pulses are formidable1. Proposals to determine biomolecular structures from diffraction experiments using femtosecond X-ray free-electron laser pulses involve a conflict between the incident brightness required to achieve diffraction-limited atomic resolution and the electronic and structural damage induced by the illumination. Significant advances have already been made, however, in the design and preparation of experiments using fourth-generation sources2 and the corresponding structural analysis of diffraction data. Here we show that previous estimates of the conditions under which biomolecular structures may be obtained in this manner are unduly restrictive, because they are based on a coherent diffraction model that is not appropriate to the proposed interaction conditions. A more detailed imaging model derived from optical coherence theory and quantum electrodynamics is shown to be far more tolerant of electronic damage. The nuclear density is employed as the principal descriptor of molecular structure. The foundations of the approach may also be used to characterize electrodynamical processes by carrying out scattering experiments on complex molecules of known structure." @default.
- W2076596341 created "2016-06-24" @default.
- W2076596341 creator A5033000618 @default.
- W2076596341 creator A5040357087 @default.
- W2076596341 date "2010-12-19" @default.
- W2076596341 modified "2023-09-23" @default.
- W2076596341 title "Biomolecular imaging and electronic damage using X-ray free-electron lasers" @default.
- W2076596341 cites W1625860372 @default.
- W2076596341 cites W1970829629 @default.
- W2076596341 cites W1978971439 @default.
- W2076596341 cites W2007593159 @default.
- W2076596341 cites W2020405262 @default.
- W2076596341 cites W2020593049 @default.
- W2076596341 cites W2042416000 @default.
- W2076596341 cites W2047732232 @default.
- W2076596341 cites W2060501150 @default.
- W2076596341 cites W2061913441 @default.
- W2076596341 cites W2067619313 @default.
- W2076596341 cites W2091462439 @default.
- W2076596341 cites W2118599105 @default.
- W2076596341 cites W2150814137 @default.
- W2076596341 cites W2159759190 @default.
- W2076596341 cites W2162416802 @default.
- W2076596341 cites W2162438244 @default.
- W2076596341 doi "https://doi.org/10.1038/nphys1859" @default.
- W2076596341 hasPublicationYear "2010" @default.
- W2076596341 type Work @default.
- W2076596341 sameAs 2076596341 @default.
- W2076596341 citedByCount "103" @default.
- W2076596341 countsByYear W20765963412012 @default.
- W2076596341 countsByYear W20765963412013 @default.
- W2076596341 countsByYear W20765963412014 @default.
- W2076596341 countsByYear W20765963412015 @default.
- W2076596341 countsByYear W20765963412016 @default.
- W2076596341 countsByYear W20765963412017 @default.
- W2076596341 countsByYear W20765963412018 @default.
- W2076596341 countsByYear W20765963412019 @default.
- W2076596341 countsByYear W20765963412020 @default.
- W2076596341 countsByYear W20765963412021 @default.
- W2076596341 countsByYear W20765963412022 @default.
- W2076596341 countsByYear W20765963412023 @default.
- W2076596341 crossrefType "journal-article" @default.
- W2076596341 hasAuthorship W2076596341A5033000618 @default.
- W2076596341 hasAuthorship W2076596341A5040357087 @default.
- W2076596341 hasBestOaLocation W20765963411 @default.
- W2076596341 hasConcept C120665830 @default.
- W2076596341 hasConcept C121332964 @default.
- W2076596341 hasConcept C125485243 @default.
- W2076596341 hasConcept C147120987 @default.
- W2076596341 hasConcept C167735695 @default.
- W2076596341 hasConcept C184779094 @default.
- W2076596341 hasConcept C207114421 @default.
- W2076596341 hasConcept C2775876984 @default.
- W2076596341 hasConcept C2781181686 @default.
- W2076596341 hasConcept C30475298 @default.
- W2076596341 hasConcept C520434653 @default.
- W2076596341 hasConcept C62520636 @default.
- W2076596341 hasConcept C77557913 @default.
- W2076596341 hasConcept C84114770 @default.
- W2076596341 hasConcept C86025842 @default.
- W2076596341 hasConcept C86453669 @default.
- W2076596341 hasConceptScore W2076596341C120665830 @default.
- W2076596341 hasConceptScore W2076596341C121332964 @default.
- W2076596341 hasConceptScore W2076596341C125485243 @default.
- W2076596341 hasConceptScore W2076596341C147120987 @default.
- W2076596341 hasConceptScore W2076596341C167735695 @default.
- W2076596341 hasConceptScore W2076596341C184779094 @default.
- W2076596341 hasConceptScore W2076596341C207114421 @default.
- W2076596341 hasConceptScore W2076596341C2775876984 @default.
- W2076596341 hasConceptScore W2076596341C2781181686 @default.
- W2076596341 hasConceptScore W2076596341C30475298 @default.
- W2076596341 hasConceptScore W2076596341C520434653 @default.
- W2076596341 hasConceptScore W2076596341C62520636 @default.
- W2076596341 hasConceptScore W2076596341C77557913 @default.
- W2076596341 hasConceptScore W2076596341C84114770 @default.
- W2076596341 hasConceptScore W2076596341C86025842 @default.
- W2076596341 hasConceptScore W2076596341C86453669 @default.
- W2076596341 hasIssue "2" @default.
- W2076596341 hasLocation W20765963411 @default.
- W2076596341 hasLocation W20765963412 @default.
- W2076596341 hasLocation W20765963413 @default.
- W2076596341 hasOpenAccess W2076596341 @default.
- W2076596341 hasPrimaryLocation W20765963411 @default.
- W2076596341 hasRelatedWork W1579191289 @default.
- W2076596341 hasRelatedWork W1967822131 @default.
- W2076596341 hasRelatedWork W1990937517 @default.
- W2076596341 hasRelatedWork W2081671628 @default.
- W2076596341 hasRelatedWork W2087281952 @default.
- W2076596341 hasRelatedWork W2166299137 @default.
- W2076596341 hasRelatedWork W2416694633 @default.
- W2076596341 hasRelatedWork W2506399527 @default.
- W2076596341 hasRelatedWork W2896137078 @default.
- W2076596341 hasRelatedWork W4296691968 @default.
- W2076596341 hasVolume "7" @default.
- W2076596341 isParatext "false" @default.
- W2076596341 isRetracted "false" @default.
- W2076596341 magId "2076596341" @default.
- W2076596341 workType "article" @default.