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- W2076603205 abstract "Abstract Primary effusion lymphoma (PEL) is a B-cell lymphoma in which human herpesvirus-8 (HHV-8) is found within all tumor cells and represents a target for selectively destroying tumor cells. HHV-8 is latent in most PEL cells and, hence, resistant to antiviral agents that inhibit lytic replication. We demonstrate that PEL cell lines containing HHV-8 without and with coinfection with Epstein-Barr virus responded to the antiseizure medication valproate with entry into the lytic cascade and production of infectious virus. Minimal cell death occurred when noninfected BL-41 cells were incubated with valproate, whereas apoptosis occurred in response to valproate in PELs that supported lytic replication of HHV-8. The anti-viral agents ganciclovir and phosphonoformic acid (PFA) blocked valproate-induced production of infectious virus without blocking entry into the lytic cascade, and apoptosis occurred at levels that were as high as when virus production was not blocked. Ganciclovir and PFA also prevented most valproate-induced expression of the late lytic viral transcript open reading frame 26 (ORF-26), but they did not block the induction of either viral interleukin-6 (vIL-6) or viral G protein-coupled receptor (vGPCR). These studies provide evidence that incubation of PELs with valproate in the presence of ganciclovir or PFA can selectively target tumor cells for apoptosis without increasing viral load." @default.
- W2076603205 created "2016-06-24" @default.
- W2076603205 creator A5009748553 @default.
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- W2076603205 creator A5038323273 @default.
- W2076603205 creator A5089376763 @default.
- W2076603205 date "2005-05-15" @default.
- W2076603205 modified "2023-10-16" @default.
- W2076603205 title "The targeting of primary effusion lymphoma cells for apoptosis by inducing lytic replication of human herpesvirus 8 while blocking virus production" @default.
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- W2076603205 doi "https://doi.org/10.1182/blood-2004-09-3569" @default.
- W2076603205 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1895088" @default.
- W2076603205 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15687238" @default.
- W2076603205 hasPublicationYear "2005" @default.
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