FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076605211> ?p ?o ?g. }

• W2076605211 endingPage "183" @default.
• W2076605211 startingPage "176" @default.
• W2076605211 abstract "Casiopeínas are a series of mixed chelate copper complexes that are being evaluated as anticancer agents. Their effects in the cell include oxidative damage and mitochondrial dysfunction, yet the molecular mechanisms leading to such effects remain unclear. We tested whether [Cu(4,7-dimethyl-phenanthroline)(glycinate)]NO(3) (Casiopeína IIgly or Cas IIgly) could alter cellular glutathione (GSH) levels by redox cycling with GSH to generate ROS and cellular oxidative stress. Cas IIgly induced a dramatic drop in intracellular levels of GSH in human lung cancer H157 and A549 cells, and is able to use GSH as source of electrons to catalyze the Fenton reaction. In both cell lines, the toxicity of Cas IIgly (2.5-5 microM) was potentiated by the GSH synthesis inhibitor l-buthionine sulfoximine (BSO) and diminished by the catalytic antioxidant manganese(III) meso-tetrakis(N,N'-diethylimidazolium-2-yl)porphyrin (MnTDE-1,3-IP(5+)), thus supporting an important role for oxidative stress. Cas IIgly also caused an over-production of reactive oxygen species (ROS) in the mitochondria and a depolarization of the mitochondrial membrane. Moreover, Cas IIgly produced mitochondrial DNA damage that resulted in an imbalance of the expression of the apoproteins of the mitochondrial respiratory chain, which also can contribute to increased ROS production. These results suggest that Cas IIgly initiates multiple possible sources of ROS over-production leading to mitochondrial dysfunction and cell death." @default.
• W2076605211 created "2016-06-24" @default.
• W2076605211 creator A5016201546 @default.
• W2076605211 creator A5052688592 @default.
• W2076605211 creator A5062159018 @default.
• W2076605211 creator A5062430469 @default.
• W2076605211 creator A5089745507 @default.
• W2076605211 date "2010-02-01" @default.
• W2076605211 modified "2023-10-18" @default.
• W2076605211 title "Casiopeína IIgly-induced oxidative stress and mitochondrial dysfunction in human lung cancer A549 and H157 cells" @default.
• W2076605211 cites W1544736820 @default.
• W2076605211 cites W1595640022 @default.
• W2076605211 cites W1965948702 @default.
• W2076605211 cites W1979374560 @default.
• W2076605211 cites W1983275110 @default.
• W2076605211 cites W1985201539 @default.
• W2076605211 cites W1989224728 @default.
• W2076605211 cites W2000926853 @default.
• W2076605211 cites W2007064404 @default.
• W2076605211 cites W2021000737 @default.
• W2076605211 cites W2023009636 @default.
• W2076605211 cites W2025095151 @default.
• W2076605211 cites W2027529665 @default.
• W2076605211 cites W2028945099 @default.
• W2076605211 cites W2033713408 @default.
• W2076605211 cites W2034035725 @default.
• W2076605211 cites W2044494908 @default.
• W2076605211 cites W2059073584 @default.
• W2076605211 cites W2063673083 @default.
• W2076605211 cites W2066638708 @default.
• W2076605211 cites W2067794175 @default.
• W2076605211 cites W2068146729 @default.
• W2076605211 cites W2072131913 @default.
• W2076605211 cites W2083437816 @default.
• W2076605211 cites W2084681121 @default.
• W2076605211 cites W2101982006 @default.
• W2076605211 cites W2104718696 @default.
• W2076605211 cites W2106465332 @default.
• W2076605211 cites W2114197585 @default.
• W2076605211 cites W2119520852 @default.
• W2076605211 cites W2119994407 @default.
• W2076605211 cites W2123488363 @default.
• W2076605211 cites W2125136235 @default.
• W2076605211 cites W2126248794 @default.
• W2076605211 cites W2140665078 @default.
• W2076605211 cites W2145694409 @default.
• W2076605211 cites W2150822910 @default.
• W2076605211 doi "https://doi.org/10.1016/j.tox.2009.12.010" @default.
• W2076605211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2826547" @default.
• W2076605211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20026372" @default.
• W2076605211 hasPublicationYear "2010" @default.
• W2076605211 type Work @default.
• W2076605211 sameAs 2076605211 @default.
• W2076605211 citedByCount "95" @default.
• W2076605211 countsByYear W20766052112012 @default.
• W2076605211 countsByYear W20766052112013 @default.
• W2076605211 countsByYear W20766052112014 @default.
• W2076605211 countsByYear W20766052112015 @default.
• W2076605211 countsByYear W20766052112016 @default.
• W2076605211 countsByYear W20766052112017 @default.
• W2076605211 countsByYear W20766052112018 @default.
• W2076605211 countsByYear W20766052112019 @default.
• W2076605211 countsByYear W20766052112020 @default.
• W2076605211 countsByYear W20766052112021 @default.
• W2076605211 countsByYear W20766052112022 @default.
• W2076605211 countsByYear W20766052112023 @default.
• W2076605211 crossrefType "journal-article" @default.
• W2076605211 hasAuthorship W2076605211A5016201546 @default.
• W2076605211 hasAuthorship W2076605211A5052688592 @default.
• W2076605211 hasAuthorship W2076605211A5062159018 @default.
• W2076605211 hasAuthorship W2076605211A5062430469 @default.
• W2076605211 hasAuthorship W2076605211A5089745507 @default.
• W2076605211 hasBestOaLocation W20766052112 @default.
• W2076605211 hasConcept C181199279 @default.
• W2076605211 hasConcept C185592680 @default.
• W2076605211 hasConcept C190283241 @default.
• W2076605211 hasConcept C2776151105 @default.
• W2076605211 hasConcept C2777476445 @default.
• W2076605211 hasConcept C2778175917 @default.
• W2076605211 hasConcept C28859421 @default.
• W2076605211 hasConcept C31573885 @default.
• W2076605211 hasConcept C48349386 @default.
• W2076605211 hasConcept C538909803 @default.
• W2076605211 hasConcept C55493867 @default.
• W2076605211 hasConcept C79879829 @default.
• W2076605211 hasConcept C81729549 @default.
• W2076605211 hasConcept C86803240 @default.
• W2076605211 hasConcept C95444343 @default.
• W2076605211 hasConcept C98274493 @default.
• W2076605211 hasConceptScore W2076605211C181199279 @default.
• W2076605211 hasConceptScore W2076605211C185592680 @default.
• W2076605211 hasConceptScore W2076605211C190283241 @default.
• W2076605211 hasConceptScore W2076605211C2776151105 @default.
• W2076605211 hasConceptScore W2076605211C2777476445 @default.
• W2076605211 hasConceptScore W2076605211C2778175917 @default.
• W2076605211 hasConceptScore W2076605211C28859421 @default.
• W2076605211 hasConceptScore W2076605211C31573885 @default.
• W2076605211 hasConceptScore W2076605211C48349386 @default.

• next