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• W2076606449 startingPage "2823" @default.
• W2076606449 abstract "Objectives: Hypercapnia is known to modulate inflammation in lungs. However, the effect of hypocapnia and hypercapnia on blood cytokine production during sepsis is not well understood. We hypothesized that CO2 modulates ex vivo inflammatory cytokine production during endotoxin stimulation. To test this hypothesis, we measured the production of pro- and anti-inflammatory cytokines in endotoxin-stimulated human whole blood cultures under hypercapnic, normocapnic, and hypocapnic conditions. Design: Prospective randomized study. Setting: Basic research laboratory. Subjects: Ten male and 10 female volunteers. Interventions: Venous blood samples, taken from volunteers were cultured at 37°C, under hypocapnic (2% CO2), normocapnic (5% CO2), and hypercapnic (7% CO2) conditions, with and without endotoxin stimulation. After 24 hrs of incubation, each culture's supernatant was analyzed for tumor necrosis factor-α, interleukin-1β, interleukin-6, interleukin-10, and interferon-γ concentrations by enzyme-linked immunosorbent assay. Data were analyzed using nonparametric repeated measures of analysis of variance followed by Dunn's multiple comparisons test. Analysis of variance with Bonferroni correction was used to compare gender differences in cytokine concentrations. The Pearson test was used to estimate correlation between hydrogen ion and individual cytokine concentrations. Measurements and Main Results: Concentrations of the proinflammatory cytokines tumor necrosis factor-α, interleukin-1β and of the anti-inflammatory cytokine interleukin-10 under hypercapnic condition were significantly decreased (p < 0.05, 0.01, and 0.001, respectively) for both genders when compared with either normocapnic or hypocapnic conditions. Concentrations of tumor necrosis factor-α and interleukin-1β were significantly higher in men. In women, concentrations of interleukin-6 were significantly decreased under hypercapnic condition when compared with hypocapnic condition. An inverse relationship was found between hydrogen ion concentration and concentrations of tumor necrosis factor-α and interleukin-10. Conclusions: Our results are consistent with the hypothesis that CO2 can affect the production of pro- and anti-inflammatory cytokines after ex vivo stimulation with endotoxin." @default.
• W2076606449 created "2016-06-24" @default.
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• W2076606449 date "2008-10-01" @default.
• W2076606449 modified "2023-09-26" @default.
• W2076606449 title "The effects of CO2 on cytokine concentrations in endotoxin-stimulated human whole blood" @default.
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• W2076606449 doi "https://doi.org/10.1097/ccm.0b013e318186f556" @default.
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