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• W2076608851 endingPage "241" @default.
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• W2076608851 abstract "The redox reactions of guanine and its widely studied oxidation product, the 8-oxo-7,8-dihydro derivative, are of significant importance for understanding the mechanisms of oxidative damage in DNA. Employing 2‘-deoxyguanosine 5‘-monophospate (dGMP) and 8-oxo-7,8-dihydro-2‘-deoxyguanosine (8-oxo-dG) in neutral aqueous solutions as model systems, we have used nanosecond laser flash photolysis to demonstrate that neutral radicals, dGMP(−H)•, derived by the one-electron oxidation and deprotonation of dGMP, can oxidize nitrite anions (NO2-) to the nitrogen dioxide radical •NO2. In turn, we show that •NO2 can give rise to a one-electron oxidation of 8-oxo-G, but not of dGMP. The one-electron oxidation of dGMP was initiated by a radical cation generated by the laser pulse-induced photoionization of a pyrene derivative with enhanced water solubility, 7,8,9,10-tetrahydroxytetrahydrobenzo[a]pyrene (BPT). The dGMP(−H)• neutral radicals formed via deprotonation of the dGMP•+ radical cations and identified by their characteristic transient absorption spectrum (λmax ∼ 310 nm) oxidize nitrite anions with a rate constant of (2.6 ± 0.3) × 106 M-1 s-1. The 8-oxo-dG is oxidized by •NO2 with a rate constant of (5.3 ± 0.5) × 106 M-1 s-1. The 8-oxo-dG(−H)• neutral radicals thus generated are clearly identified by their characteristic transient absorption spectra (λmax ∼ 320 nm). The rate constant of 8-oxo-dG oxidation (k12) by the •NO2 one-electron oxidant (the •NO2/NO2- redox potential, E° ≈ 1.04 V vs NHE) is lower than k12 for a series of oxidizing aromatic radical cations with known redox potentials. The k12 values for 8-oxo-dG oxidation by different aromatic radical cations derived from the photoionization of their parent compounds depend on the redox potentials of the latter, which were in the range of 0.8−1.6 V versus NHE. The magnitude of k12 gradually decreases from a value of 2.2 × 109 M-1 s-1 (E° = 1.62 V) to 5.8 × 108 M-1 s-1 (E° = 1.13 V) and eventually to 5 × 107 M-1 s-1 (E° = 0.91 V). The implications of these results, including the possibility that the redox cycling of the •NO2/NO2- species can be involved in the further oxidative damage of 8-oxo-dG in DNA in cellular environments, are discussed." @default.
• W2076608851 created "2016-06-24" @default.
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• W2076608851 date "2001-01-25" @default.
• W2076608851 modified "2023-10-17" @default.
• W2076608851 title "Nitrogen Dioxide as an Oxidizing Agent of 8-Oxo-7,8-dihydro-2‘-deoxyguanosine but Not of 2‘-Deoxyguanosine" @default.
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• W2076608851 doi "https://doi.org/10.1021/tx000204t" @default.
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