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• W2076609553 startingPage "349" @default.
• W2076609553 abstract "Bone balances serum pH variations and both osteoclasts and osteoblasts are regulated by subtle changes in pH. The aim of the current study was to identify molecules in bone that can sense pH. Interesting candidates are the acid-sensing ion channels (ASICs). In bone, ASIC2 and ASIC3 were most abundant, while in chondrocytes it was ASIC1. Isolated human monocytes expressed ASIC1, -2, and -3, which persisted after induction to osteoclast differentiation, albeit to a lower level. In human osteoblasts ASIC1, ASIC2, and ASIC3 mRNAs were shown. Western blot and immunostaining confirmed this at protein level. ASIC4 expression was always very low abundant. For the first time, we demonstrated ASICs in human skeleton, providing a means to sense and respond to differences in extracellular pH." @default.
• W2076609553 created "2016-06-24" @default.
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• W2076609553 date "2005-11-01" @default.
• W2076609553 modified "2023-10-14" @default.
• W2076609553 title "Identification of acid-sensing ion channels in bone" @default.
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• W2076609553 doi "https://doi.org/10.1016/j.bbrc.2005.09.054" @default.
• W2076609553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16185661" @default.
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