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- W2076609940 abstract "Neuronal production in metazoans is tightly controlled by Delta/Notch-dependent signals regulating lateral inhibition. It is currently thought that lateral inhibition takes place in clusters of precursors with equal capacity to trigger and receive Notch-dependent inhibitory signals. However, this view neglects crucial dynamical aspects of the process. In this review, we discuss two of these dynamic factors, whose alterations yield dysfunctions in neurogenesis. First, precursors show variable neurogenic capacity as they go through the cell cycle. Second, differentiating precursors are in direct contact with non-neurogenic cells at the wavefront of expanding neurogenic domains. We discuss the mechanisms adopted by Metazoa to prevent these dysfunctions in the lateral inhibitory process, which include cell cycle synchronization occurring in the invertebrate neural epithelium and during primary neurogenesis in anamniotes, interkinetic nuclear movement in the vertebrate neuroepithelium and generalized Delta expression ahead of the neurogenic wavefront. The emerging concept is that lateral inhibition during neurogenesis occurs in dynamic clusters of precursors and requires specific mechanisms to avoid distortions resulting from the interaction between neurogenic and non-neurogenic precursors. The advance in visualizing Notch dynamics with real-time imaging at cellular and subcellular levels will notably contribute to our understanding of these novel aspects of motion in neurogenesis." @default.
- W2076609940 created "2016-06-24" @default.
- W2076609940 creator A5015672525 @default.
- W2076609940 creator A5033551106 @default.
- W2076609940 creator A5035212900 @default.
- W2076609940 creator A5042488015 @default.
- W2076609940 date "2013-01-01" @default.
- W2076609940 modified "2023-10-16" @default.
- W2076609940 title "Lateral inhibition and neurogenesis: novel aspects in motion" @default.
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- W2076609940 doi "https://doi.org/10.1387/ijdb.120259jf" @default.
- W2076609940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23873365" @default.
- W2076609940 hasPublicationYear "2013" @default.
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