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• W2076612721 abstract "The first case of bilateral metachronous periosteal osteosarcoma (OS) is reported. A 14-year-old white boy presented with a 1-month history of pain and swelling in his right thigh. Periosteal OS was diagnosed on a basis of the radiologic and pathologic findings. Treatment was with local resection and total hip replacement after a short course of high-dose methotrexate; multi-agent chemotherapy was continued postoperatively for 3 months. He remained well for 3 years. He then represented with a mass in the left femur that had been slowly growing for about 1 year. Radiologic and biopsy studies showed periosteal OS. Full investigations showed no evidence of metastatic disease. Treatment consisted of local resection without chemotherapy. He remained well for 6 months after the second excision until developing multiple pulmonary metastases. All further therapy was refused. The question as to whether the second tumor was a new primary lesion or a metastasis is discussed, together with possible differential diagnoses. Cancer 58:1139-1143, 1986." @default.
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• W2076612721 date "1986-09-01" @default.
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• W2076612721 title "Bilateral metachronous periosteal osteosarcoma" @default.
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• W2076612721 doi "https://doi.org/10.1002/1097-0142(19860901)58:5<1139::aid-cncr2820580527>3.0.co;2-a" @default.
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