FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076615095> ?p ?o ?g. }

• W2076615095 endingPage "6534" @default.
• W2076615095 startingPage "6521" @default.
• W2076615095 abstract "The interaction of chromomycin A3 with the oligodeoxyribonucleotides 1, d(ATGCAT), 2, d(ATCGAT), 3, d(TATGCATA), and 4, d(ATAGCTAT), has been investigated by 1H and 31P NMR. In the presence of Mg2+, chromomycin binds strongly to the three GC-containing oligomers 1, 3, and 4 but not to the CG-containing oligomer 2. The proton chemical shift changes for 1 and 3 are similar, and these DNA duplexes appear to bind with a stoichiometry of 2 drugs:1 Mg2+:1 duplex. The same stoichiometry of 2 drugs:1 duplex is confirmed with 4; however, proton chemical shift changes differ. An overall C2 symmetry is exhibited by the drug complex with 1, 3, and 4. At a molar ratio of 2.0 (drugs:duplex), no free DNA proton NMR signals remain. Two-dimensional nuclear Overhauser exchange spectroscopy (NOESY) of the saturated chromomycin complex with 1 and 3 positions both chromomycinone hydroxyls and the E carbohydrates in the minor groove and provides evidence suggesting that the B carbohydrates lie on the major-groove side. This is supported by several dipolar coupling cross-peaks between the drug and the DNA duplex. Drug-induced conformational changes in duplex 1 are evaluated over a range of NOESY mixing times and found to possess some characteristics of both B-DNA and A-DNA, where the minor groove is wider and shallower. A widening of the minor groove is essential for the DNA duplex to accommodate two drug molecules. This current minor-groove model is a substantial revision of our earlier major-groove model [Keniry, M.A., Brown, S.C., Berman, E., & Shafer, R.H. (1987) Biochemistry 26, 1058-1067] and is in agreement with the model recently proposed by Gao and Patel [Gao, X., & Patel, D. J. (1989a) Biochemistry 28, 751-762]." @default.
• W2076615095 created "2016-06-24" @default.
• W2076615095 creator A5002418169 @default.
• W2076615095 creator A5032510435 @default.
• W2076615095 creator A5037918909 @default.
• W2076615095 creator A5084790319 @default.
• W2076615095 date "1990-07-10" @default.
• W2076615095 modified "2023-09-26" @default.
• W2076615095 title "NMR studies of the interaction of chromomycin A3 with small DNA duplexes. Binding to GC-containing sequences" @default.
• W2076615095 cites W1477446189 @default.
• W2076615095 cites W1563135275 @default.
• W2076615095 cites W1571547416 @default.
• W2076615095 cites W1965987734 @default.
• W2076615095 cites W1966532055 @default.
• W2076615095 cites W1969776708 @default.
• W2076615095 cites W1972220947 @default.
• W2076615095 cites W1973801914 @default.
• W2076615095 cites W1974115528 @default.
• W2076615095 cites W1984417251 @default.
• W2076615095 cites W1992692759 @default.
• W2076615095 cites W1993554908 @default.
• W2076615095 cites W1994081513 @default.
• W2076615095 cites W1995126685 @default.
• W2076615095 cites W1995386269 @default.
• W2076615095 cites W1999915701 @default.
• W2076615095 cites W2004861068 @default.
• W2076615095 cites W2005667593 @default.
• W2076615095 cites W2010528272 @default.
• W2076615095 cites W2012114552 @default.
• W2076615095 cites W2016903468 @default.
• W2076615095 cites W2022633361 @default.
• W2076615095 cites W2024800690 @default.
• W2076615095 cites W2026094497 @default.
• W2076615095 cites W2027058762 @default.
• W2076615095 cites W2037046846 @default.
• W2076615095 cites W2037284121 @default.
• W2076615095 cites W2042332275 @default.
• W2076615095 cites W2047661094 @default.
• W2076615095 cites W2053971511 @default.
• W2076615095 cites W2055213294 @default.
• W2076615095 cites W2061849233 @default.
• W2076615095 cites W2062611387 @default.
• W2076615095 cites W2065095908 @default.
• W2076615095 cites W2083560387 @default.
• W2076615095 cites W2086887513 @default.
• W2076615095 cites W2091425095 @default.
• W2076615095 cites W2093700493 @default.
• W2076615095 cites W2118824970 @default.
• W2076615095 cites W2331243937 @default.
• W2076615095 cites W2949250147 @default.
• W2076615095 doi "https://doi.org/10.1021/bi00479a026" @default.
• W2076615095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2207094" @default.
• W2076615095 hasPublicationYear "1990" @default.
• W2076615095 type Work @default.
• W2076615095 sameAs 2076615095 @default.
• W2076615095 citedByCount "48" @default.
• W2076615095 countsByYear W20766150952014 @default.
• W2076615095 countsByYear W20766150952023 @default.
• W2076615095 crossrefType "journal-article" @default.
• W2076615095 hasAuthorship W2076615095A5002418169 @default.
• W2076615095 hasAuthorship W2076615095A5032510435 @default.
• W2076615095 hasAuthorship W2076615095A5037918909 @default.
• W2076615095 hasAuthorship W2076615095A5084790319 @default.
• W2076615095 hasConcept C103319777 @default.
• W2076615095 hasConcept C103435993 @default.
• W2076615095 hasConcept C112887158 @default.
• W2076615095 hasConcept C119851462 @default.
• W2076615095 hasConcept C178790620 @default.
• W2076615095 hasConcept C185592680 @default.
• W2076615095 hasConcept C19549132 @default.
• W2076615095 hasConcept C2780933421 @default.
• W2076615095 hasConcept C32909587 @default.
• W2076615095 hasConcept C552990157 @default.
• W2076615095 hasConcept C55493867 @default.
• W2076615095 hasConcept C66974803 @default.
• W2076615095 hasConcept C71240020 @default.
• W2076615095 hasConcept C8010536 @default.
• W2076615095 hasConcept C83640560 @default.
• W2076615095 hasConcept C99611785 @default.
• W2076615095 hasConceptScore W2076615095C103319777 @default.
• W2076615095 hasConceptScore W2076615095C103435993 @default.
• W2076615095 hasConceptScore W2076615095C112887158 @default.
• W2076615095 hasConceptScore W2076615095C119851462 @default.
• W2076615095 hasConceptScore W2076615095C178790620 @default.
• W2076615095 hasConceptScore W2076615095C185592680 @default.
• W2076615095 hasConceptScore W2076615095C19549132 @default.
• W2076615095 hasConceptScore W2076615095C2780933421 @default.
• W2076615095 hasConceptScore W2076615095C32909587 @default.
• W2076615095 hasConceptScore W2076615095C552990157 @default.
• W2076615095 hasConceptScore W2076615095C55493867 @default.
• W2076615095 hasConceptScore W2076615095C66974803 @default.
• W2076615095 hasConceptScore W2076615095C71240020 @default.
• W2076615095 hasConceptScore W2076615095C8010536 @default.
• W2076615095 hasConceptScore W2076615095C83640560 @default.
• W2076615095 hasConceptScore W2076615095C99611785 @default.
• W2076615095 hasIssue "27" @default.
• W2076615095 hasLocation W20766150951 @default.
• W2076615095 hasLocation W20766150952 @default.

• next