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- W2076616054 abstract "Additive and synergistic interactions between hemopoietic growth factors and cytokines (Interleukins and colony stimulating factors) can be demonstrated in vitro in clonogenic and suspension cultures of murine and human bone Inarrow. Purification of early stem cells by combinations of purging .~ith.cytotoxic-agents (5fluorouracil, 4-HP cyclophosphamide) and selection with monoclonal antibodies for CD34+, CD33cells permits analysis of factor interactions at the level of the primitive pluripotential stem cell. Interactions between IL-l, IL-6, TNF, G-, GMand M-CSF, and IL-3 can be monitored. vivo, In IL-l alone, or in combination with G-CSF, produces accelerated reconstitution of hemopoiesis after chemotherapy, irradiation and bone marrow transplantation in murine and primate systems. IL-1 is directly radioprotective in vitro on populations of human hematopoietic stem cells. In addition IL-1 elicits cytokine cascades that may have positive or negative actions on lymphohemopoiesis. Induction of oroaucts of th cyclooxygenase and lipoxygenase pathways, as well as tumor necrosis factor and TGF-beta, modulate hemopoiesis. Recent clinical trials usinq G-CSF in patients with idiopathic or congenital disorders have demonstrated increases in peripheral blood neutrophil counts. The etiology of these disorders remains obscure but we have analvzed the structure of the G-CSF qene bv Southern blottinq. as well as the inducibilitv of G-CSF mRNA and bioactive G-CSF in bone marrow fibroblasts: -Trans-modulation.of growth factor and cytokine receptors on neutrophils, monocytes, and possibly early progenitors are also involved in these complex regulatory interactions." @default.
- W2076616054 created "2016-06-24" @default.
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- W2076616054 date "1989-01-01" @default.
- W2076616054 modified "2023-09-24" @default.
- W2076616054 title "Cytokine networks in congenital, idiopathic and iatrogenic neutropenia" @default.
- W2076616054 doi "https://doi.org/10.1016/0360-3016(89)90626-3" @default.
- W2076616054 hasPublicationYear "1989" @default.
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