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• W2076616209 abstract "✓ Direct electrical current (DC) was applied to the basilar artery of 20 dogs and the circle of Willis of five monkeys. The artery was in contact with microsurgical forceps acting as the monopolar electrode. The DC currents from 0 to 1 mA were used at voltages of 0 to 3 V with observable effect noted at levels above 0.5 mA at 1 V. Neither negative (−) nor positive (+) DC caused vasoconstriction unless the initial and terminal current change occurred too rapidly causing a stimulus pulse. Both − and + DC caused focal vasodilatation of the artery made spastic by needle puncture or topical 10% barium chloride (BaCl 2 ). This dilatation was more rapid (30 to 60 sec) and more pronounced with −DC current. Angiography confirmed extreme focal dilatation lasting at least 4 days after −DC application. This appears to be secondary to the known production of hydroxyl (OH − ) ions at the cathode and possibly hydrogen (H + or H 3 O + ) ions at the anode during electrolysis. We hypothesize that smooth muscle protein bonds are affected. The effects of DC on the systemic arteries also are described. Also studied were the effects of similar DC on brain cortical microvasculature of 10 dogs and on the systemic arteries of 50 rats. It was discovered that not only did + DC cause the well-known local coagulation phenomena but also both − and + DC caused formation of micro-emboli with resulting occlusion of arterioles. These phenomena, which could be seen only under the operating microscope, occurred after a decomposition potential of about 1 V was reached. We theorize this was due to the formation of denatured protein and alkali-hematin at the − pole secondary to the formation of OH − ions during electrolytic reduction and due to formation of denatured protein and acid-hematin at the + pole secondary to the formation of H+ ions during electrolytic oxidation. For reasons not yet clear there was an acute breakdown in the blood-brain barrier to fluorescein around the negative pole but not around the positive pole." @default.
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• W2076616209 date "1974-11-01" @default.
• W2076616209 modified "2023-10-14" @default.
• W2076616209 title "The experimental effect of direct electrical current on intracranial arteries and the blood-brain barrier" @default.
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• W2076616209 doi "https://doi.org/10.3171/jns.1974.41.5.0582" @default.
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