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• W2076627336 abstract "To sustain the effect of rivastigmine, a hydrophilic cholinesterase inhibitor, nanobased formulations were prepared. The efficacy of the prepared rivastigmine liposomes (RLs) in comparison to rivastigmine solution (RS) was assessed in an aluminium chloride (AlCl(3))-induced Alzheimer's model.Liposomes were prepared by lipid hydration (F1) and heating (F2) methods. Rats were treated with either RS or RLs (1 mg/kg/day) concomitantly with AlCl(3) (50 mg/kg/day).The study showed that the F1 method produced smaller liposomes (67.51 ± 14.2 nm) than F2 (528.7 ± 15.5 nm), but both entrapped the same amount of the drug (92.1% ± 1.4%). After 6 hours, 74.2% ± 1.5% and 60.8% ± 2.3% of rivastigmine were released from F1 and F2, respectively. Both RLs and RS improved the deterioration of spatial memory induced by AlCl(3), with RLs having a superior effect. Further biochemical measurements proved that RS and RLs were able to lower plasma C-reactive protein, homocysteine and asymmetric dimethy-larginine levels. RS significantly attenuated acetylcholinesterase (AChE) activity, whereas Na(+)/K(+)-adenosine triphosphatase (ATPase) activity was enhanced compared to the AlCl(3)-treated animals; however, RLs succeeded in normalization of AChE and Na(+)/K(+) ATPase activities. Gene-expression profile showed that cotreatment with RS to AlCl(3)-treated rats succeeded in exerting significant decreases in BACE1, AChE, and IL1B gene expression. Normalization of the expression of the aforementioned genes was achieved by coadministration of RLs to AlCl(3)-treated rats. The profound therapeutic effect of RLs over RS was evidenced by nearly preventing amyloid plaque formation, as shown in the histopathological examination of rat brain.RLs could be a potential drug-delivery system for ameliorating Alzheimer's disease." @default.
• W2076627336 created "2016-06-24" @default.
• W2076627336 creator A5003479691 @default.
• W2076627336 creator A5032800421 @default.
• W2076627336 creator A5039635084 @default.
• W2076627336 date "2013-01-01" @default.
• W2076627336 modified "2023-10-13" @default.
• W2076627336 title "Potential therapeutic effect of nanobased formulation of rivastigmine on rat model of Alzheimer&#39;s disease" @default.
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• W2076627336 doi "https://doi.org/10.2147/ijn.s39232" @default.
• W2076627336 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3558309" @default.
• W2076627336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23378761" @default.
• W2076627336 hasPublicationYear "2013" @default.
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