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- W2076628087 abstract "The reaction of 5-amino-3-methylisoxazole with appropriate α,β-unsaturated ketones gave the corresponding isoxazolo[5,4-b]pyridines. Treatment of 1 with 2,6-dibenzylidenecyclohexanone or 2-benzylidenedimedone afforded the corresponding isoxazolo[5,4-b]quinoline derivatives. 4,6,8,9-Tetrahydroisoxazolo[5,4-b]quinolin-5-one derivative was also obtained by multicomponent condensation reaction of 1 with dimedone and benzaldehyde. Heterocyclic annulation of the isoxazolo[5,4-b]pyridine system was achieved via reaction of 1 with benzylidene derivatives of indandione, quinuclidone, pyrazolone, and oxazolone. A representative of some newly synthesized compounds was evaluated as antitumor agents." @default.
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- W2076628087 date "2012-03-02" @default.
- W2076628087 modified "2023-10-18" @default.
- W2076628087 title "Efficient Regioselective Synthesis and Potential Antitumor Evaluation of Isoxazolo[5,4-<i>b</i>]pyridines and Related Annulated Compounds" @default.
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- W2076628087 doi "https://doi.org/10.1002/ardp.201100258" @default.
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