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- W2076631467 abstract "Drugs which are weak acids or weak bases and drugs with limited water solubility are more toxic by the oral route when given in dilute solution or suspension. The onset of sleep after po administration of sodium pentobarbital (50 mg/kg) is faster in rats when the drug is given in dilute solution (5 ml/100 g body wt) than when it is given in concentrated solution (0.5 ml/100 g body wt). However, administration of water po (5 ml/100 g body wt) does not affect the ip toxicity of aminopyrine. Sodium salicylate plasma levels are significantly higher in rats after the drug is given po in dilute (0.8%) solution than when it is given po in concentrated (25%) solution. These data indicate that drugs are absorbed more rapidly into the systemic circulation when given po in dilute rather than concentrated solution. Two mechanisms appear to be involved in the increased toxicity phenomenon with low concentrations of drugs: (1) rapid stomach emptying and (2) exposure to a large absorptive surface of drug solutions given po in a relatively large fluid volume." @default.
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- W2076631467 date "1971-06-01" @default.
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- W2076631467 title "Mechanism of enhanced drug effects produced by dilution of the oral dose" @default.
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- W2076631467 doi "https://doi.org/10.1016/0041-008x(71)90103-7" @default.
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