FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076633810> ?p ?o ?g. }

• W2076633810 endingPage "1265" @default.
• W2076633810 startingPage "1259" @default.
• W2076633810 abstract "OBJECTIVE. The purpose of this article is to study the imaging features, management, and outcome of pneumatosis intestinalis and bowel perforation associated with molecular targeted therapy. MATERIALS AND METHODS. In this retrospective study, 48 patients with cancer who developed pneumatosis or intestinal perforation were found by searching a radiology database. Of these patients, 24 patients (13 women and 11 men; mean age, 61 years; range, 39–83 years) receiving molecular targeted therapy without any confounding factors for pneumatosis or perforation were selected. Initial and follow-up CT scans were evaluated by two radiologists; medical records were reviewed to note clinical features, management, and outcome. RESULTS. Seventeen (70.8%) patients were asymptomatic. Colorectal cancer (n = 10) and renal cell carcinoma (n = 5) were the most common malignancies; bevacizumab (n = 14) and sunitinib (n = 6) were the most common associated drugs. Imaging findings included intestinal perforation (20 sites in 18 patients), pneumatosis (n = 10), ascites (n = 8), pneumoperitoneum (n = 7), fistula formation (n = 7), and fluid collections (six collections in five patients). Fifteen (62.5%) patients were treated conservatively, seven (29.2%) underwent surgery, and two (8.3%) underwent percutaneous drainage. Molecular targeted therapy was discontinued in 22 of 24 patients; findings resolved in 19 patients, remained stable in one, and worsened in one. One patient died after surgery. In both instances where the drug was continued, the abnormality worsened. Findings recurred in three of four patients in whom the drug was restarted after initial resolution. CONCLUSION. Radiologists should be aware of intestinal complications associated with molecular targeted therapy, including pneumatosis, bowel perforation, and fistula formation. Most patients can be treated conservatively after discontinuation of molecular targeted therapy. Continuing or restarting molecular targeted therapy can cause worsening or recurrent pneumatosis or perforation." @default.
• W2076633810 created "2016-06-24" @default.
• W2076633810 creator A5000204340 @default.
• W2076633810 creator A5017560192 @default.
• W2076633810 creator A5042555322 @default.
• W2076633810 creator A5048398844 @default.
• W2076633810 creator A5070044404 @default.
• W2076633810 creator A5091622849 @default.
• W2076633810 date "2012-12-01" @default.
• W2076633810 modified "2023-10-01" @default.
• W2076633810 title "Pneumatosis Intestinalis and Bowel Perforation Associated With Molecular Targeted Therapy: An Emerging Problem and the Role of Radiologists in Its Management" @default.
• W2076633810 cites W1825428369 @default.
• W2076633810 cites W1973183162 @default.
• W2076633810 cites W1987238029 @default.
• W2076633810 cites W1988901044 @default.
• W2076633810 cites W2002270485 @default.
• W2076633810 cites W2003290732 @default.
• W2076633810 cites W2005008001 @default.
• W2076633810 cites W2015311968 @default.
• W2076633810 cites W2027038235 @default.
• W2076633810 cites W2053438624 @default.
• W2076633810 cites W2059293297 @default.
• W2076633810 cites W2060281755 @default.
• W2076633810 cites W2079852644 @default.
• W2076633810 cites W2089617058 @default.
• W2076633810 cites W2096615702 @default.
• W2076633810 cites W2097995306 @default.
• W2076633810 cites W2104938382 @default.
• W2076633810 cites W2112648254 @default.
• W2076633810 cites W2122217676 @default.
• W2076633810 cites W2134061119 @default.
• W2076633810 cites W2137582962 @default.
• W2076633810 cites W2139511378 @default.
• W2076633810 cites W2140765540 @default.
• W2076633810 cites W2141100300 @default.
• W2076633810 cites W2157769714 @default.
• W2076633810 cites W2320083939 @default.
• W2076633810 cites W2487815795 @default.
• W2076633810 cites W4242070356 @default.
• W2076633810 cites W4289258260 @default.
• W2076633810 cites W2016300243 @default.
• W2076633810 doi "https://doi.org/10.2214/ajr.12.8782" @default.
• W2076633810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23169717" @default.
• W2076633810 hasPublicationYear "2012" @default.
• W2076633810 type Work @default.
• W2076633810 sameAs 2076633810 @default.
• W2076633810 citedByCount "85" @default.
• W2076633810 countsByYear W20766338102013 @default.
• W2076633810 countsByYear W20766338102014 @default.
• W2076633810 countsByYear W20766338102015 @default.
• W2076633810 countsByYear W20766338102016 @default.
• W2076633810 countsByYear W20766338102017 @default.
• W2076633810 countsByYear W20766338102018 @default.
• W2076633810 countsByYear W20766338102019 @default.
• W2076633810 countsByYear W20766338102020 @default.
• W2076633810 countsByYear W20766338102021 @default.
• W2076633810 countsByYear W20766338102022 @default.
• W2076633810 countsByYear W20766338102023 @default.
• W2076633810 crossrefType "journal-article" @default.
• W2076633810 hasAuthorship W2076633810A5000204340 @default.
• W2076633810 hasAuthorship W2076633810A5017560192 @default.
• W2076633810 hasAuthorship W2076633810A5042555322 @default.
• W2076633810 hasAuthorship W2076633810A5048398844 @default.
• W2076633810 hasAuthorship W2076633810A5070044404 @default.
• W2076633810 hasAuthorship W2076633810A5091622849 @default.
• W2076633810 hasConcept C126322002 @default.
• W2076633810 hasConcept C126838900 @default.
• W2076633810 hasConcept C141071460 @default.
• W2076633810 hasConcept C167135981 @default.
• W2076633810 hasConcept C191897082 @default.
• W2076633810 hasConcept C192562407 @default.
• W2076633810 hasConcept C2777910003 @default.
• W2076633810 hasConcept C2778456384 @default.
• W2076633810 hasConcept C2778527123 @default.
• W2076633810 hasConcept C2778582513 @default.
• W2076633810 hasConcept C2778746874 @default.
• W2076633810 hasConcept C2780047204 @default.
• W2076633810 hasConcept C71924100 @default.
• W2076633810 hasConceptScore W2076633810C126322002 @default.
• W2076633810 hasConceptScore W2076633810C126838900 @default.
• W2076633810 hasConceptScore W2076633810C141071460 @default.
• W2076633810 hasConceptScore W2076633810C167135981 @default.
• W2076633810 hasConceptScore W2076633810C191897082 @default.
• W2076633810 hasConceptScore W2076633810C192562407 @default.
• W2076633810 hasConceptScore W2076633810C2777910003 @default.
• W2076633810 hasConceptScore W2076633810C2778456384 @default.
• W2076633810 hasConceptScore W2076633810C2778527123 @default.
• W2076633810 hasConceptScore W2076633810C2778582513 @default.
• W2076633810 hasConceptScore W2076633810C2778746874 @default.
• W2076633810 hasConceptScore W2076633810C2780047204 @default.
• W2076633810 hasConceptScore W2076633810C71924100 @default.
• W2076633810 hasIssue "6" @default.
• W2076633810 hasLocation W20766338101 @default.
• W2076633810 hasLocation W20766338102 @default.
• W2076633810 hasOpenAccess W2076633810 @default.
• W2076633810 hasPrimaryLocation W20766338101 @default.
• W2076633810 hasRelatedWork W1980277662 @default.
• W2076633810 hasRelatedWork W2031463845 @default.

• next