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• W2076637239 abstract "The term “supernumerary teeth” describes production of more than the normal number of teeth in the primary or permanent dentitions. Their aetiology is not understood. Uterine sensitization associated gene-1 (USAG-1) is a BMP antagonist that plays important roles in the local regulation of BMP signaling by binding and neutralizing BMP activities [M. Yanagita, BMP antagonists: their roles in development and involvement in pathophysiology, Cytokine Growth Factor Rev. 16 (2005) 309–317], and also serves as a modulator of Wnt signaling [N. Itasaki, C.M. Jones, S. Mercurio, A. Rowe, P.M. Domingos, J.C. Smith, R. Krumlauf, Wise, a context-dependent activator and inhibitor of Wnt signaling, Development 130 (2003) 4295–4305]. We report here that USAG-1 deficient mice have supernumerary teeth. The supernumerary maxillary incisor appears to form as a result of the successive development of the rudimentary upper incisor tooth. We confirmed that the USAG-1 expression is localized to the epithelium and mesenchyme of the rudimentary maxillary incisor tooth organ formation. USAG-1 abrogation rescued apoptotic elimination of odontogenic mesenchymal cells. Based upon these results, we conclude that USAG-1 controls the number of teeth in the maxillary incisor region by regulating apoptosis." @default.
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• W2076637239 date "2007-08-01" @default.
• W2076637239 modified "2023-10-12" @default.
• W2076637239 title "Rudiment incisors survive and erupt as supernumerary teeth as a result of USAG-1 abrogation" @default.
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• W2076637239 doi "https://doi.org/10.1016/j.bbrc.2007.05.148" @default.
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