Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076637570> ?p ?o ?g. }
- W2076637570 endingPage "343" @default.
- W2076637570 startingPage "337" @default.
- W2076637570 abstract "Plasma homocysteine has been reported to be useful in the evaluation of patients with suspected vitamin B12 or folate deficiency. In November 1998, Canada began its mandatory fortification of all flour, and some corn and rice products, with folic acid. We evaluated the status of folate and vitamin B12 in Ontario since this fortification program began, and also studied the role of plasma homocysteine in the assessment of vitamin B12 deficiency since that time.A retrospective cross-sectional study design was performed using a community database of all Ontario samples analyzed by MDS Laboratories, a major provider of diagnostic laboratory services in Canada. All consecutive single-patient fasting samples for plasma homocysteine collected between January 1 and September 30, 1999 were included, as well as corresponding red cell folate and serum B12 concentrations. Data for serum folate were included when available. Descriptive statistics included the arithmetic and geometric means for each measure, as well as the lower and upper centile values. After excluding cases with a concomitant serum creatinine > 120 micromol/L or red cell folate < 215 nmol/L, we established the test properties of a plasma homocyteine level of 15 micromol/L or greater for the diagnosis of low (< 120 pmol/L) or indeterminate (i.e., between 120 and 150 pmol/L) serum vitamin B12 concentrations.The mean age of all subjects was 58.4 years (95% CI 57.4 to 59.4). Plasma homocysteine samples were obtained from 403 males (56.7%) and 308 females. The geometric mean homocysteine concentration for the entire population was 8.3 micromol/L, and was significantly higher among males (9.3 micromol/L) than females (8.3 micromol/L) (unpaired t-test: 2-p < 0.0001). The geometric mean serum folate concentration was significantly higher in females (35.8 nmol/L) than males (33.6 nmol/L) (2-p < 0.0001), as were the mean red cell folate levels (females 966.8 nmol/L, males 949.3 nmol/L; 2-p < 0.0001). Serum vitamin B12 concentrations were available for 692 subjects, with a geometric mean of 322.0 pmol/L. Again, mean vitamin B12 was higher in females (332.5 pmol/L) than males (314.3 pmol/L) (2-p < 0.0001). The fifth centile for vitamin B12 was 134.6 pmol/L. A plasma homocysteine concentration > 15 micromol/L did not discriminate between cobalamin concentrations below versus above 120 pmol/L (positive and negative predictive values 7.4% and 97.2%, respectively), nor did it discriminate indeterminate B12 levels between 120 and 150 pmol/L (positive and negative predictive values 6.3% and 94.0%, respectively).In a large select group of Ontarians, serum and red cell folate concentrations appear to be higher than expected, possibly due to a recent national folate fortification programme; cobalamin levels are no higher than expected. Given our inability to detect mild B12 deficiency using such indicators as plasma homocysteine, and considering the substantial growth in the elderly segment of the Canadian population, occult cobalamin deficiency could become a common disorder. Accordingly, we recommend either consideration of the addition of vitamin B12 to the current folate fortification programme, and/or the development of better methods for the detection of cobalamin deficiency." @default.
- W2076637570 created "2016-06-24" @default.
- W2076637570 creator A5001067933 @default.
- W2076637570 creator A5010230431 @default.
- W2076637570 creator A5070237544 @default.
- W2076637570 date "2000-07-01" @default.
- W2076637570 modified "2023-10-09" @default.
- W2076637570 title "An Ontario-wide study of vitamin B12, serum folate, and red cell folate levels in relation to plasma homocysteine: is a preventable public health issue on the rise?" @default.
- W2076637570 cites W1552489252 @default.
- W2076637570 cites W1665594410 @default.
- W2076637570 cites W1689606519 @default.
- W2076637570 cites W1964281166 @default.
- W2076637570 cites W1966697095 @default.
- W2076637570 cites W1975963693 @default.
- W2076637570 cites W1979184328 @default.
- W2076637570 cites W1997067835 @default.
- W2076637570 cites W2000864446 @default.
- W2076637570 cites W2004931493 @default.
- W2076637570 cites W2009031512 @default.
- W2076637570 cites W2021156126 @default.
- W2076637570 cites W2022888328 @default.
- W2076637570 cites W2029187079 @default.
- W2076637570 cites W2051136548 @default.
- W2076637570 cites W2063596326 @default.
- W2076637570 cites W2064912482 @default.
- W2076637570 cites W2066688265 @default.
- W2076637570 cites W2077725073 @default.
- W2076637570 cites W2091210469 @default.
- W2076637570 cites W2094455110 @default.
- W2076637570 cites W2125756592 @default.
- W2076637570 cites W2126486540 @default.
- W2076637570 cites W2151667576 @default.
- W2076637570 cites W2156756679 @default.
- W2076637570 cites W2165985110 @default.
- W2076637570 cites W2166278013 @default.
- W2076637570 cites W2166383386 @default.
- W2076637570 cites W2323783182 @default.
- W2076637570 cites W3021628120 @default.
- W2076637570 cites W4211037353 @default.
- W2076637570 cites W4241703202 @default.
- W2076637570 cites W4241821999 @default.
- W2076637570 doi "https://doi.org/10.1016/s0009-9120(00)00083-7" @default.
- W2076637570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11018684" @default.
- W2076637570 hasPublicationYear "2000" @default.
- W2076637570 type Work @default.
- W2076637570 sameAs 2076637570 @default.
- W2076637570 citedByCount "74" @default.
- W2076637570 countsByYear W20766375702012 @default.
- W2076637570 countsByYear W20766375702013 @default.
- W2076637570 countsByYear W20766375702014 @default.
- W2076637570 countsByYear W20766375702015 @default.
- W2076637570 countsByYear W20766375702017 @default.
- W2076637570 countsByYear W20766375702018 @default.
- W2076637570 countsByYear W20766375702019 @default.
- W2076637570 countsByYear W20766375702021 @default.
- W2076637570 countsByYear W20766375702022 @default.
- W2076637570 crossrefType "journal-article" @default.
- W2076637570 hasAuthorship W2076637570A5001067933 @default.
- W2076637570 hasAuthorship W2076637570A5010230431 @default.
- W2076637570 hasAuthorship W2076637570A5070237544 @default.
- W2076637570 hasConcept C126322002 @default.
- W2076637570 hasConcept C185592680 @default.
- W2076637570 hasConcept C198211336 @default.
- W2076637570 hasConcept C2776523773 @default.
- W2076637570 hasConcept C2777090595 @default.
- W2076637570 hasConcept C2779750884 @default.
- W2076637570 hasConcept C2780306776 @default.
- W2076637570 hasConcept C2780829489 @default.
- W2076637570 hasConcept C2908647359 @default.
- W2076637570 hasConcept C3017560507 @default.
- W2076637570 hasConcept C31903555 @default.
- W2076637570 hasConcept C71924100 @default.
- W2076637570 hasConcept C90924648 @default.
- W2076637570 hasConcept C99454951 @default.
- W2076637570 hasConceptScore W2076637570C126322002 @default.
- W2076637570 hasConceptScore W2076637570C185592680 @default.
- W2076637570 hasConceptScore W2076637570C198211336 @default.
- W2076637570 hasConceptScore W2076637570C2776523773 @default.
- W2076637570 hasConceptScore W2076637570C2777090595 @default.
- W2076637570 hasConceptScore W2076637570C2779750884 @default.
- W2076637570 hasConceptScore W2076637570C2780306776 @default.
- W2076637570 hasConceptScore W2076637570C2780829489 @default.
- W2076637570 hasConceptScore W2076637570C2908647359 @default.
- W2076637570 hasConceptScore W2076637570C3017560507 @default.
- W2076637570 hasConceptScore W2076637570C31903555 @default.
- W2076637570 hasConceptScore W2076637570C71924100 @default.
- W2076637570 hasConceptScore W2076637570C90924648 @default.
- W2076637570 hasConceptScore W2076637570C99454951 @default.
- W2076637570 hasIssue "5" @default.
- W2076637570 hasLocation W20766375701 @default.
- W2076637570 hasLocation W20766375702 @default.
- W2076637570 hasOpenAccess W2076637570 @default.
- W2076637570 hasPrimaryLocation W20766375701 @default.
- W2076637570 hasRelatedWork W1964670765 @default.
- W2076637570 hasRelatedWork W2001013436 @default.
- W2076637570 hasRelatedWork W2022728683 @default.
- W2076637570 hasRelatedWork W2384052284 @default.
- W2076637570 hasRelatedWork W2417564905 @default.