Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076638654> ?p ?o ?g. }
- W2076638654 endingPage "146" @default.
- W2076638654 startingPage "129" @default.
- W2076638654 abstract "Recent EU/US pediatric legislation and FDA/EMEA guidelines recognize the potential differences in safety profiles of drugs in adults versus young patients. Hence safety studies are recommended to investigate key functional domains of e.g. the developing CNS.Selected psychoactive stimulants (caffeine, d-amphetamine, scopolamine) and depressants (baclofen, diazepam, haloperidol, chlorpromazine, imipramine, morphine) were characterized upon single administration with regard to behavioural parameters, locomotor activity, body temperature, pro-/anti-convulsive activity (pentylenetetrazole, PTZ), and nocifensive responses (hotplate) in neonatal (2 weeks), juvenile (4 weeks) and adult rats (8-9 weeks).In vehicle-treated rats, behavioural patterns matured with age, locomotor activity and handling-induced rise in body temperature were enhanced, whereas PTZ convulsion threshold dose and nocifensive response latency decreased. Single test compound treatment elicited behavioural effects characteristic for psychoactive drugs with stimulating and depressing properties regardless of age. However, incidence of certain behaviours, and magnitude of effects on locomotor activity and body temperature varied with age and became generally more pronounced in adult rats. Pro-/anti-convulsive effects and delayed nocifensive responses did not differ between juvenile and adult rats.CNS effects of selected psychoactive reference compounds were qualitatively similar, but quantitatively different in neonatal, juvenile and adult rats." @default.
- W2076638654 created "2016-06-24" @default.
- W2076638654 creator A5070883929 @default.
- W2076638654 date "2008-09-01" @default.
- W2076638654 modified "2023-09-25" @default.
- W2076638654 title "Safety pharmacology assessment of central nervous system function in juvenile and adult rats: Effects of pharmacological reference compounds" @default.
- W2076638654 cites W139299909 @default.
- W2076638654 cites W1551663317 @default.
- W2076638654 cites W1824285989 @default.
- W2076638654 cites W1915010695 @default.
- W2076638654 cites W1963492138 @default.
- W2076638654 cites W1965577041 @default.
- W2076638654 cites W1966838418 @default.
- W2076638654 cites W1972715667 @default.
- W2076638654 cites W1975145835 @default.
- W2076638654 cites W1975380821 @default.
- W2076638654 cites W1975980905 @default.
- W2076638654 cites W1978275630 @default.
- W2076638654 cites W1978292464 @default.
- W2076638654 cites W1978620166 @default.
- W2076638654 cites W1979460153 @default.
- W2076638654 cites W1979567871 @default.
- W2076638654 cites W1982249577 @default.
- W2076638654 cites W1984569853 @default.
- W2076638654 cites W1984671860 @default.
- W2076638654 cites W1985648594 @default.
- W2076638654 cites W1986698383 @default.
- W2076638654 cites W1987752502 @default.
- W2076638654 cites W1988192817 @default.
- W2076638654 cites W1988201643 @default.
- W2076638654 cites W1988781968 @default.
- W2076638654 cites W1993685476 @default.
- W2076638654 cites W1993846198 @default.
- W2076638654 cites W1994092577 @default.
- W2076638654 cites W1995871906 @default.
- W2076638654 cites W1996001779 @default.
- W2076638654 cites W1996808726 @default.
- W2076638654 cites W1998692061 @default.
- W2076638654 cites W1999979314 @default.
- W2076638654 cites W2002684358 @default.
- W2076638654 cites W2003615600 @default.
- W2076638654 cites W2004296516 @default.
- W2076638654 cites W2004597915 @default.
- W2076638654 cites W2004995830 @default.
- W2076638654 cites W2005049943 @default.
- W2076638654 cites W2007858185 @default.
- W2076638654 cites W2007912185 @default.
- W2076638654 cites W2008481231 @default.
- W2076638654 cites W2010526028 @default.
- W2076638654 cites W2012553932 @default.
- W2076638654 cites W2012950060 @default.
- W2076638654 cites W2013453209 @default.
- W2076638654 cites W2013888840 @default.
- W2076638654 cites W2013998151 @default.
- W2076638654 cites W2014044731 @default.
- W2076638654 cites W2016524500 @default.
- W2076638654 cites W2016897045 @default.
- W2076638654 cites W2017280945 @default.
- W2076638654 cites W2017918858 @default.
- W2076638654 cites W2018455224 @default.
- W2076638654 cites W2019854210 @default.
- W2076638654 cites W2022133841 @default.
- W2076638654 cites W2022728099 @default.
- W2076638654 cites W2022741440 @default.
- W2076638654 cites W2023906412 @default.
- W2076638654 cites W2023971815 @default.
- W2076638654 cites W2025524300 @default.
- W2076638654 cites W2025564492 @default.
- W2076638654 cites W2027958051 @default.
- W2076638654 cites W2028686624 @default.
- W2076638654 cites W2028851705 @default.
- W2076638654 cites W2029806817 @default.
- W2076638654 cites W2033762218 @default.
- W2076638654 cites W2034966901 @default.
- W2076638654 cites W203559137 @default.
- W2076638654 cites W2035672988 @default.
- W2076638654 cites W2036386442 @default.
- W2076638654 cites W2037362968 @default.
- W2076638654 cites W2037692843 @default.
- W2076638654 cites W2037843433 @default.
- W2076638654 cites W2038833468 @default.
- W2076638654 cites W2040544575 @default.
- W2076638654 cites W2041223345 @default.
- W2076638654 cites W2041691811 @default.
- W2076638654 cites W2041731838 @default.
- W2076638654 cites W2043709750 @default.
- W2076638654 cites W2043994402 @default.
- W2076638654 cites W2045278471 @default.
- W2076638654 cites W2047662887 @default.
- W2076638654 cites W2048506497 @default.
- W2076638654 cites W2049735743 @default.
- W2076638654 cites W2050346984 @default.
- W2076638654 cites W2050682362 @default.
- W2076638654 cites W2051344448 @default.
- W2076638654 cites W2052704225 @default.
- W2076638654 cites W2052940264 @default.
- W2076638654 cites W2060299786 @default.
- W2076638654 cites W2061256107 @default.