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- W2076645574 abstract "The von Hippel–Lindau (VHL) tumor suppressor gene is a protein interaction hub, controlling numerous genes implicated in tumor progression. Here we focus on structural aspects of protein interactions for a list of 35 experimentally verified protein VHL (pVHL) interactors. Using structural information and computational analysis we have located three distinct interaction interfaces (A, B, and C). Interface B is the most versatile, recognizing a refined linear motif present in 17 otherwise non-related proteins. It has been possible to distinguish compatible and exclusive interactions by relating pVHL function to interaction interfaces and subcellular localization. A novel hypothesis is presented regarding the possible function of the N-terminus as an inhibitor of pVHL function." @default.
- W2076645574 created "2016-06-24" @default.
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- W2076645574 creator A5066560665 @default.
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- W2076645574 date "2009-10-28" @default.
- W2076645574 modified "2023-09-25" @default.
- W2076645574 title "Adding structural information to the von Hippel-Lindau (VHL) tumor suppressor interaction network" @default.
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- W2076645574 doi "https://doi.org/10.1016/j.febslet.2009.10.070" @default.
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