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• W2076645585 endingPage "10413" @default.
• W2076645585 startingPage "10404" @default.
• W2076645585 abstract "Although Ca2+/calmodulin-dependent protein kinase II (CaMKII) is enriched at the presynaptic nerve terminal, its role in neurotransmitter release is poorly defined. We assessed the function of presynaptic CaMKII in neurotransmitter release and tested the hypothesis that BK channel is a mediator of presynaptic CaMKII function by analyzing miniature and evoked postsynaptic currents at the Caenorhabditis elegans neuromuscular junction. Both loss-of-function (lf) and gain-of-function (gf) of unc-43, the gene encoding CaMKII, inhibited neurotransmitter release. The inhibitory effect of unc-43(gf) was reversed by mutation or blockade of the BK channel SLO-1. SLO-1 expressed in Xenopus oocytes could be activated by recombinant rat alpha-CaMKII, and this effect of CaMKII was abolished by mutating a threonine residue (T425) at a consensus CaMKII phosphorylation site in the first RCK (regulator of conductance for K+) domain of the channel. Expression of slo-1(T425A) in neurons antagonized the inhibitory effect of unc-43(gf) on neurotransmitter release as slo-1(lf) did. The inhibitory effect of unc-43(gf) was not reversed by unc-103(lf), dgk-1(lf), or eat-16(lf), which reportedly suppress behavioral phenotypes of unc-43(gf). These observations suggest that presynaptic CaMKII is a bidirectional modulator of neurotransmitter release, presumably by phosphorylating different molecular targets, and that its negative modulatory effect on the release is mainly mediated by SLO-1 activation." @default.
• W2076645585 created "2016-06-24" @default.
• W2076645585 creator A5008544250 @default.
• W2076645585 creator A5010260063 @default.
• W2076645585 creator A5068625652 @default.
• W2076645585 creator A5075372349 @default.
• W2076645585 date "2007-09-26" @default.
• W2076645585 modified "2023-09-27" @default.
• W2076645585 title "Presynaptic Ca²⁺/Calmodulin-Dependent Protein Kinase II Modulates Neurotransmitter Release by Activating BK Channels at<i>Caenorhabditis elegans</i>Neuromuscular Junction" @default.
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• W2076645585 doi "https://doi.org/10.1523/jneurosci.5634-06.2007" @default.
• W2076645585 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6673169" @default.
• W2076645585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17898212" @default.
• W2076645585 hasPublicationYear "2007" @default.
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