FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076647527> ?p ?o ?g. }

• W2076647527 endingPage "815" @default.
• W2076647527 startingPage "805" @default.
• W2076647527 abstract "In the Heterosexual AIDS Transmission Study (HATS), the frequency of high-risk sexual activity and viral load in the seropositive partner were shown to correlate with HIV-1 transmission. However, these parameters could not account for the status of some exposed, seronegative (ESN) individuals who remained uninfected despite years of exposure. To test the hypothesis that antiviral immune responses are a correlate of nontransmission in this cohort, we developed two sensitive methods for assessing HIV-1-specific humoral and cell-mediated responses. To quantify T cell responses, autologous mature dendritic cells (DCs) were used as antigen-presenting cells to elicit HIV-1-specific IFN-gamma production by ELISPOT. Antibody responses to HIV-1 gp120 were assessed by combination immunoprecipitation-Western blot (IP-WB). Previous studies of this cohort, using limiting dilution analysis, did not reveal HIV-1-specific cytotoxic T lymphocyte activity. However, when autologous DCs were used to present HIV-1 antigens, T cells from three of eight ESN women (38%) responded by producing IFN-gamma. T cells from three of four seropositive partners responded to HIV-1 antigens, whereas five negative controls did not. The use of DCs as antigen-presenting cells increased sensitivity by 2- to 30-fold relative to standard ELISPOT. Using IP-WB, low levels of gp120-reactive antibodies were detected in plasma from 1 of 14 ESN women. These results support the hypothesis that HIV-1-specific T cell responses play a role in immune surveillance in this cohort of North American serodiscordant couples. This report also demonstrates the ability of dendritic cells to reveal T cell responses that might be overlooked by other methods." @default.
• W2076647527 created "2016-06-24" @default.
• W2076647527 creator A5017796724 @default.
• W2076647527 creator A5018517926 @default.
• W2076647527 creator A5045314017 @default.
• W2076647527 creator A5055252960 @default.
• W2076647527 creator A5055358847 @default.
• W2076647527 creator A5062454377 @default.
• W2076647527 creator A5067039452 @default.
• W2076647527 creator A5069221243 @default.
• W2076647527 creator A5087719434 @default.
• W2076647527 creator A5088286282 @default.
• W2076647527 creator A5091850865 @default.
• W2076647527 date "2002-07-20" @default.
• W2076647527 modified "2023-10-06" @default.
• W2076647527 title "Dendritic Cell Amplification of HIV Type 1-Specific CD8⁺T Cell Responses in Exposed, Seronegative Heterosexual Women" @default.
• W2076647527 cites W1544323280 @default.
• W2076647527 cites W1561591381 @default.
• W2076647527 cites W1779647240 @default.
• W2076647527 cites W1867913228 @default.
• W2076647527 cites W1973591436 @default.
• W2076647527 cites W1974647588 @default.
• W2076647527 cites W1974906492 @default.
• W2076647527 cites W1981355816 @default.
• W2076647527 cites W1983888219 @default.
• W2076647527 cites W1987046764 @default.
• W2076647527 cites W1998724551 @default.
• W2076647527 cites W2000776156 @default.
• W2076647527 cites W2001079898 @default.
• W2076647527 cites W2008366157 @default.
• W2076647527 cites W2032458422 @default.
• W2076647527 cites W2033431358 @default.
• W2076647527 cites W2035555649 @default.
• W2076647527 cites W2041643036 @default.
• W2076647527 cites W2043147184 @default.
• W2076647527 cites W2048999843 @default.
• W2076647527 cites W2067560365 @default.
• W2076647527 cites W2073766421 @default.
• W2076647527 cites W2077325919 @default.
• W2076647527 cites W2077776638 @default.
• W2076647527 cites W2079176471 @default.
• W2076647527 cites W2080138798 @default.
• W2076647527 cites W2080350299 @default.
• W2076647527 cites W2090630729 @default.
• W2076647527 cites W2096234619 @default.
• W2076647527 cites W2099460024 @default.
• W2076647527 cites W2103059036 @default.
• W2076647527 cites W2107474172 @default.
• W2076647527 cites W2110898276 @default.
• W2076647527 cites W2117745315 @default.
• W2076647527 cites W2121372003 @default.
• W2076647527 cites W2128016589 @default.
• W2076647527 cites W2132088341 @default.
• W2076647527 cites W2138265888 @default.
• W2076647527 cites W2138773604 @default.
• W2076647527 cites W2142405752 @default.
• W2076647527 cites W2143329914 @default.
• W2076647527 cites W2143977260 @default.
• W2076647527 cites W2145031719 @default.
• W2076647527 cites W2149195560 @default.
• W2076647527 cites W2154011163 @default.
• W2076647527 cites W2157104740 @default.
• W2076647527 cites W2161529269 @default.
• W2076647527 cites W2162543584 @default.
• W2076647527 cites W2164617202 @default.
• W2076647527 cites W2168122647 @default.
• W2076647527 cites W2169324657 @default.
• W2076647527 cites W2171499092 @default.
• W2076647527 cites W2320392364 @default.
• W2076647527 cites W2325887155 @default.
• W2076647527 cites W2333122403 @default.
• W2076647527 cites W2411407737 @default.
• W2076647527 doi "https://doi.org/10.1089/08892220260139558" @default.
• W2076647527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12167272" @default.
• W2076647527 hasPublicationYear "2002" @default.
• W2076647527 type Work @default.
• W2076647527 sameAs 2076647527 @default.
• W2076647527 citedByCount "18" @default.
• W2076647527 countsByYear W20766475272012 @default.
• W2076647527 countsByYear W20766475272014 @default.
• W2076647527 countsByYear W20766475272015 @default.
• W2076647527 countsByYear W20766475272022 @default.
• W2076647527 countsByYear W20766475272023 @default.
• W2076647527 crossrefType "journal-article" @default.
• W2076647527 hasAuthorship W2076647527A5017796724 @default.
• W2076647527 hasAuthorship W2076647527A5018517926 @default.
• W2076647527 hasAuthorship W2076647527A5045314017 @default.
• W2076647527 hasAuthorship W2076647527A5055252960 @default.
• W2076647527 hasAuthorship W2076647527A5055358847 @default.
• W2076647527 hasAuthorship W2076647527A5062454377 @default.
• W2076647527 hasAuthorship W2076647527A5067039452 @default.
• W2076647527 hasAuthorship W2076647527A5069221243 @default.
• W2076647527 hasAuthorship W2076647527A5087719434 @default.
• W2076647527 hasAuthorship W2076647527A5088286282 @default.
• W2076647527 hasAuthorship W2076647527A5091850865 @default.
• W2076647527 hasConcept C147483822 @default.
• W2076647527 hasConcept C154317977 @default.
• W2076647527 hasConcept C159047783 @default.

• next