FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076649598> ?p ?o ?g. }

• W2076649598 endingPage "865" @default.
• W2076649598 startingPage "852" @default.
• W2076649598 abstract "Abstract Background: Complex regional pain syndrome (CRPS) is a painful condition with approximately 50,000 annual new cases in the United States. It is a major cause of work-related disability, chronic pain after limb fractures, and persistent pain after extremity surgery. Additionally, CRPS patients often experience cognitive changes, anxiety, and depression. The supraspinal mechanisms linked to these CRPS-related comorbidities remain poorly understood. Methods: The authors used a previously characterized mouse model of tibia fracture/cast immobilization showing the principal stigmata of CRPS (n = 8 to 20 per group) observed in humans. The central hypothesis was that fracture/cast mice manifest changes in measures of thigmotaxis (indicative of anxiety) and working memory reflected in neuroplastic changes in amygdala, perirhinal cortex, and hippocampus. Results: The authors demonstrate that nociceptive sensitization in these mice is accompanied by altered thigmotactic behaviors in the zero maze but not open field assay, and working memory dysfunction in novel object recognition and social memory but not in novel location recognition. Furthermore, the authors found evidence of structural changes and synaptic plasticity including changes in dendritic architecture and decreased levels of synaptophysin and brain-derived neurotrophic factor in specific brain regions. Conclusions: The study findings provide novel observations regarding behavioral changes and brain plasticity in a mouse model of CRPS. In addition to elucidating some of the supraspinal correlates of the syndrome, this work supports the potential use of therapeutic interventions that not only directly target sensory input and other peripheral mechanisms, but also attempt to ameliorate the broader pain experience by modifying its associated cognitive and emotional comorbidities." @default.
• W2076649598 created "2016-06-24" @default.
• W2076649598 creator A5005327915 @default.
• W2076649598 creator A5017701312 @default.
• W2076649598 creator A5021668017 @default.
• W2076649598 creator A5034163193 @default.
• W2076649598 creator A5035862770 @default.
• W2076649598 creator A5049621128 @default.
• W2076649598 creator A5056384169 @default.
• W2076649598 creator A5056947162 @default.
• W2076649598 creator A5062546791 @default.
• W2076649598 creator A5068488754 @default.
• W2076649598 creator A5085516263 @default.
• W2076649598 date "2014-10-01" @default.
• W2076649598 modified "2023-10-14" @default.
• W2076649598 title "Brain Neuroplastic Changes Accompany Anxiety and Memory Deficits in a Model of Complex Regional Pain Syndrome" @default.
• W2076649598 cites W1946372678 @default.
• W2076649598 cites W1966037459 @default.
• W2076649598 cites W1966310971 @default.
• W2076649598 cites W1966351569 @default.
• W2076649598 cites W1966734675 @default.
• W2076649598 cites W1969716910 @default.
• W2076649598 cites W1970321055 @default.
• W2076649598 cites W1974409272 @default.
• W2076649598 cites W1976024859 @default.
• W2076649598 cites W1981646138 @default.
• W2076649598 cites W1985282754 @default.
• W2076649598 cites W1987615735 @default.
• W2076649598 cites W1990891103 @default.
• W2076649598 cites W1994043711 @default.
• W2076649598 cites W1998054425 @default.
• W2076649598 cites W2001308670 @default.
• W2076649598 cites W2008162423 @default.
• W2076649598 cites W2008800555 @default.
• W2076649598 cites W2009597693 @default.
• W2076649598 cites W2010147928 @default.
• W2076649598 cites W2015262351 @default.
• W2076649598 cites W2021256327 @default.
• W2076649598 cites W2021396128 @default.
• W2076649598 cites W2024032885 @default.
• W2076649598 cites W2025176554 @default.
• W2076649598 cites W2025407174 @default.
• W2076649598 cites W2027751288 @default.
• W2076649598 cites W2028055839 @default.
• W2076649598 cites W2029985169 @default.
• W2076649598 cites W2032847834 @default.
• W2076649598 cites W2033438673 @default.
• W2076649598 cites W2038211748 @default.
• W2076649598 cites W2038390533 @default.
• W2076649598 cites W2038709220 @default.
• W2076649598 cites W2038813826 @default.
• W2076649598 cites W2039496891 @default.
• W2076649598 cites W2045962631 @default.
• W2076649598 cites W2047177002 @default.
• W2076649598 cites W2050069080 @default.
• W2076649598 cites W2055051732 @default.
• W2076649598 cites W2056039338 @default.
• W2076649598 cites W2061915937 @default.
• W2076649598 cites W2066597177 @default.
• W2076649598 cites W2068671706 @default.
• W2076649598 cites W2069178273 @default.
• W2076649598 cites W2071358232 @default.
• W2076649598 cites W2076445235 @default.
• W2076649598 cites W2077313724 @default.
• W2076649598 cites W2077993736 @default.
• W2076649598 cites W2078425802 @default.
• W2076649598 cites W2079472132 @default.
• W2076649598 cites W2080049061 @default.
• W2076649598 cites W2081113831 @default.
• W2076649598 cites W2081265466 @default.
• W2076649598 cites W2081369904 @default.
• W2076649598 cites W2082456105 @default.
• W2076649598 cites W2087278902 @default.
• W2076649598 cites W2089419837 @default.
• W2076649598 cites W2090391179 @default.
• W2076649598 cites W2094205815 @default.
• W2076649598 cites W2095335650 @default.
• W2076649598 cites W2095901107 @default.
• W2076649598 cites W2099102233 @default.
• W2076649598 cites W2100545292 @default.
• W2076649598 cites W2102837445 @default.
• W2076649598 cites W2106926631 @default.
• W2076649598 cites W2110475454 @default.
• W2076649598 cites W2113712314 @default.
• W2076649598 cites W2115347480 @default.
• W2076649598 cites W2117693696 @default.
• W2076649598 cites W2118629794 @default.
• W2076649598 cites W2120200946 @default.
• W2076649598 cites W2131110619 @default.
• W2076649598 cites W2137553663 @default.
• W2076649598 cites W2142155886 @default.
• W2076649598 cites W2142295577 @default.
• W2076649598 cites W2143532919 @default.
• W2076649598 cites W2144531560 @default.
• W2076649598 cites W2144569263 @default.
• W2076649598 cites W2144854156 @default.
• W2076649598 cites W2144933081 @default.
• W2076649598 cites W2152686904 @default.

• next