FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076655202> ?p ?o ?g. }

• W2076655202 endingPage "e73737" @default.
• W2076655202 startingPage "e73737" @default.
• W2076655202 abstract "Aldosterone binds to the mineralocorticoid receptor (MR) and exerts pleiotropic effects beyond enhancing renal sodium reabsorption. Excessive mineralocorticoid signaling is deleterious during the evolution of cardiac failure, as evidenced by the benefits provided by adding MR antagonists (MRA) to standard care in humans. In animal models of cardiovascular diseases, MRA reduce cardiac fibrosis. Interestingly diuretics such as torasemide also appear efficient to improve cardiovascular morbidity and mortality, through several mechanisms. Among them, it has been suggested that torasemide could block aldosterone binding to the MR. To evaluate whether torasemide acts as a MRA in cardiomyocytes, we compared its effects with a classic MRA such as spironolactone. We monitored ligand-induced nuclear translocation of MR-GFP and MR transactivation activity in the cardiac-like cell line H9C2 using a reporter gene assay and known endogenous aldosterone-regulated cardiac genes. Torasemide did not modify MR nuclear translocation. Aldosterone-induced MR transactivation activity was reduced by the MRA spironolactone, not by torasemide. Spironolactone blocked the induction by aldosterone of endogenous MR-responsive genes (Sgk-1, PAI-1, Orosomucoid-1, Rgs-2, Serpina-3, Tenascin-X), while torasemide was ineffective. These results show that torasemide is not an MR antagonist; its association with MRA in heart failure may however be beneficial, through actions on complementary pathways." @default.
• W2076655202 created "2016-06-24" @default.
• W2076655202 creator A5010231452 @default.
• W2076655202 creator A5019636543 @default.
• W2076655202 creator A5027065690 @default.
• W2076655202 creator A5033960054 @default.
• W2076655202 creator A5055415045 @default.
• W2076655202 creator A5061827333 @default.
• W2076655202 creator A5062027594 @default.
• W2076655202 date "2013-09-09" @default.
• W2076655202 modified "2023-10-18" @default.
• W2076655202 title "The Diuretic Torasemide Does Not Prevent Aldosterone-Mediated Mineralocorticoid Receptor Activation in Cardiomyocytes" @default.
• W2076655202 cites W1507538191 @default.
• W2076655202 cites W1973676137 @default.
• W2076655202 cites W1978894148 @default.
• W2076655202 cites W1980407134 @default.
• W2076655202 cites W2000719141 @default.
• W2076655202 cites W2010162415 @default.
• W2076655202 cites W2018603271 @default.
• W2076655202 cites W2027847781 @default.
• W2076655202 cites W2028338937 @default.
• W2076655202 cites W2042079149 @default.
• W2076655202 cites W2055725306 @default.
• W2076655202 cites W2057108655 @default.
• W2076655202 cites W2060016301 @default.
• W2076655202 cites W2062093782 @default.
• W2076655202 cites W2062321035 @default.
• W2076655202 cites W2065350647 @default.
• W2076655202 cites W2079740085 @default.
• W2076655202 cites W2079780982 @default.
• W2076655202 cites W2081402100 @default.
• W2076655202 cites W2081719923 @default.
• W2076655202 cites W2084639732 @default.
• W2076655202 cites W2085770656 @default.
• W2076655202 cites W2086793695 @default.
• W2076655202 cites W2087060187 @default.
• W2076655202 cites W2098994127 @default.
• W2076655202 cites W2108244474 @default.
• W2076655202 cites W2123496533 @default.
• W2076655202 cites W2128139685 @default.
• W2076655202 cites W2129911320 @default.
• W2076655202 cites W2137852986 @default.
• W2076655202 cites W2140855779 @default.
• W2076655202 cites W2150426711 @default.
• W2076655202 cites W2152094259 @default.
• W2076655202 cites W2159788200 @default.
• W2076655202 cites W2159942116 @default.
• W2076655202 cites W2160194184 @default.
• W2076655202 cites W2164705414 @default.
• W2076655202 cites W2166381668 @default.
• W2076655202 cites W2168777122 @default.
• W2076655202 cites W2182021623 @default.
• W2076655202 cites W2323458614 @default.
• W2076655202 doi "https://doi.org/10.1371/journal.pone.0073737" @default.
• W2076655202 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3767808" @default.
• W2076655202 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24040049" @default.
• W2076655202 hasPublicationYear "2013" @default.
• W2076655202 type Work @default.
• W2076655202 sameAs 2076655202 @default.
• W2076655202 citedByCount "30" @default.
• W2076655202 countsByYear W20766552022014 @default.
• W2076655202 countsByYear W20766552022015 @default.
• W2076655202 countsByYear W20766552022016 @default.
• W2076655202 countsByYear W20766552022017 @default.
• W2076655202 countsByYear W20766552022018 @default.
• W2076655202 countsByYear W20766552022019 @default.
• W2076655202 countsByYear W20766552022020 @default.
• W2076655202 countsByYear W20766552022021 @default.
• W2076655202 countsByYear W20766552022022 @default.
• W2076655202 countsByYear W20766552022023 @default.
• W2076655202 crossrefType "journal-article" @default.
• W2076655202 hasAuthorship W2076655202A5010231452 @default.
• W2076655202 hasAuthorship W2076655202A5019636543 @default.
• W2076655202 hasAuthorship W2076655202A5027065690 @default.
• W2076655202 hasAuthorship W2076655202A5033960054 @default.
• W2076655202 hasAuthorship W2076655202A5055415045 @default.
• W2076655202 hasAuthorship W2076655202A5061827333 @default.
• W2076655202 hasAuthorship W2076655202A5062027594 @default.
• W2076655202 hasBestOaLocation W20766552021 @default.
• W2076655202 hasConcept C104317684 @default.
• W2076655202 hasConcept C126322002 @default.
• W2076655202 hasConcept C1292079 @default.
• W2076655202 hasConcept C134018914 @default.
• W2076655202 hasConcept C189135053 @default.
• W2076655202 hasConcept C198710026 @default.
• W2076655202 hasConcept C2776069600 @default.
• W2076655202 hasConcept C2776379505 @default.
• W2076655202 hasConcept C2778198053 @default.
• W2076655202 hasConcept C2778525890 @default.
• W2076655202 hasConcept C2780249997 @default.
• W2076655202 hasConcept C2781117629 @default.
• W2076655202 hasConcept C55493867 @default.
• W2076655202 hasConcept C71924100 @default.
• W2076655202 hasConcept C84393581 @default.
• W2076655202 hasConcept C86339819 @default.
• W2076655202 hasConcept C86803240 @default.
• W2076655202 hasConcept C98274493 @default.
• W2076655202 hasConceptScore W2076655202C104317684 @default.

• next