FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076662006> ?p ?o ?g. }

• W2076662006 endingPage "960" @default.
• W2076662006 startingPage "953" @default.
• W2076662006 abstract "We recently reported that sphingosylphosphorylcholine (SPC) is a novel messenger for Rho-kinase-mediated Ca(2+) sensitization of vascular smooth muscle (VSM) contraction. Subcellular localization and kinase activity of Src family protein kinases (SrcPTKs), except for c-Src, is controlled by a reversible S-palmitoylation, an event inhibited by eicosapentaenoic acid (EPA). We examined the possible involvement of SrcPTKs in SPC-induced Ca(2+) sensitization and effects of EPA. We used porcine coronary VSM and rat aortic VSM cells (VSMCs) in primary culture. An SrcPTKs inhibitor, PP1, and EPA inhibited SPC-induced contraction, concentration-dependently, without affecting [Ca(2+)](i) levels and the Ca(2+)-dependent contraction induced by high K(+) depolarization. A digitized immunocytochemical analysis in VSMCs revealed that SPC induced translocation of Fyn, but not of c-Src, from the cytosol to the cell membrane, an event abolished by EPA. Translocation of Rho-kinase from the cytosol to the cell membrane by SPC was also inhibited by EPA and PP1. The SPC-induced activation of SrcPTKs was blocked by EPA and PP1, but not by Y27632, an Rho-kinase inhibitor. Rho-kinase-dependent phosphorylation of myosin phosphatase induced by SPC was inhibited by EPA, PP1, and Y27632. Translocation and activation of SrcPTKs, including Fyn, play an important role in Ca(2+) sensitization of VSM contractions mediated by a SPC-Rho-kinase pathway." @default.
• W2076662006 created "2016-06-24" @default.
• W2076662006 creator A5004191574 @default.
• W2076662006 creator A5017011235 @default.
• W2076662006 creator A5030594159 @default.
• W2076662006 creator A5054558163 @default.
• W2076662006 creator A5066378738 @default.
• W2076662006 creator A5068682760 @default.
• W2076662006 creator A5069255706 @default.
• W2076662006 creator A5080940034 @default.
• W2076662006 creator A5084661301 @default.
• W2076662006 date "2002-11-15" @default.
• W2076662006 modified "2023-10-07" @default.
• W2076662006 title "Involvement of Src Family Protein Tyrosine Kinases in Ca ²⁺ Sensitization of Coronary Artery Contraction Mediated by a Sphingosylphosphorylcholine-Rho-Kinase Pathway" @default.
• W2076662006 cites W1494227533 @default.
• W2076662006 cites W1514066364 @default.
• W2076662006 cites W1963728493 @default.
• W2076662006 cites W1978675594 @default.
• W2076662006 cites W1980358798 @default.
• W2076662006 cites W1984107562 @default.
• W2076662006 cites W1985285041 @default.
• W2076662006 cites W1986619046 @default.
• W2076662006 cites W1987162518 @default.
• W2076662006 cites W1993379452 @default.
• W2076662006 cites W2000293531 @default.
• W2076662006 cites W2003904482 @default.
• W2076662006 cites W2007009112 @default.
• W2076662006 cites W2010720361 @default.
• W2076662006 cites W2026102591 @default.
• W2076662006 cites W2030202169 @default.
• W2076662006 cites W2032295238 @default.
• W2076662006 cites W2035589742 @default.
• W2076662006 cites W2043834087 @default.
• W2076662006 cites W2061229454 @default.
• W2076662006 cites W2073535369 @default.
• W2076662006 cites W2085060915 @default.
• W2076662006 cites W2090895449 @default.
• W2076662006 cites W2092263034 @default.
• W2076662006 cites W2104886379 @default.
• W2076662006 cites W2104901736 @default.
• W2076662006 cites W2114844324 @default.
• W2076662006 cites W2115427263 @default.
• W2076662006 cites W2137985055 @default.
• W2076662006 cites W2142475134 @default.
• W2076662006 cites W2160864876 @default.
• W2076662006 cites W2169976308 @default.
• W2076662006 cites W4247898116 @default.
• W2076662006 doi "https://doi.org/10.1161/01.res.0000042702.04920.bf" @default.
• W2076662006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12433841" @default.
• W2076662006 hasPublicationYear "2002" @default.
• W2076662006 type Work @default.
• W2076662006 sameAs 2076662006 @default.
• W2076662006 citedByCount "89" @default.
• W2076662006 countsByYear W20766620062012 @default.
• W2076662006 countsByYear W20766620062013 @default.
• W2076662006 countsByYear W20766620062014 @default.
• W2076662006 countsByYear W20766620062015 @default.
• W2076662006 countsByYear W20766620062016 @default.
• W2076662006 countsByYear W20766620062017 @default.
• W2076662006 countsByYear W20766620062018 @default.
• W2076662006 countsByYear W20766620062020 @default.
• W2076662006 countsByYear W20766620062021 @default.
• W2076662006 countsByYear W20766620062022 @default.
• W2076662006 countsByYear W20766620062023 @default.
• W2076662006 crossrefType "journal-article" @default.
• W2076662006 hasAuthorship W2076662006A5004191574 @default.
• W2076662006 hasAuthorship W2076662006A5017011235 @default.
• W2076662006 hasAuthorship W2076662006A5030594159 @default.
• W2076662006 hasAuthorship W2076662006A5054558163 @default.
• W2076662006 hasAuthorship W2076662006A5066378738 @default.
• W2076662006 hasAuthorship W2076662006A5068682760 @default.
• W2076662006 hasAuthorship W2076662006A5069255706 @default.
• W2076662006 hasAuthorship W2076662006A5080940034 @default.
• W2076662006 hasAuthorship W2076662006A5084661301 @default.
• W2076662006 hasBestOaLocation W20766620061 @default.
• W2076662006 hasConcept C108636557 @default.
• W2076662006 hasConcept C11960822 @default.
• W2076662006 hasConcept C184235292 @default.
• W2076662006 hasConcept C185592680 @default.
• W2076662006 hasConcept C199217515 @default.
• W2076662006 hasConcept C201800478 @default.
• W2076662006 hasConcept C2779976819 @default.
• W2076662006 hasConcept C42362537 @default.
• W2076662006 hasConcept C55493867 @default.
• W2076662006 hasConcept C62478195 @default.
• W2076662006 hasConcept C86803240 @default.
• W2076662006 hasConcept C90934575 @default.
• W2076662006 hasConcept C95444343 @default.
• W2076662006 hasConcept C97029542 @default.
• W2076662006 hasConceptScore W2076662006C108636557 @default.
• W2076662006 hasConceptScore W2076662006C11960822 @default.
• W2076662006 hasConceptScore W2076662006C184235292 @default.
• W2076662006 hasConceptScore W2076662006C185592680 @default.
• W2076662006 hasConceptScore W2076662006C199217515 @default.
• W2076662006 hasConceptScore W2076662006C201800478 @default.
• W2076662006 hasConceptScore W2076662006C2779976819 @default.
• W2076662006 hasConceptScore W2076662006C42362537 @default.
• W2076662006 hasConceptScore W2076662006C55493867 @default.

• next