FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076663174> ?p ?o ?g. }

• W2076663174 endingPage "1116" @default.
• W2076663174 startingPage "1105" @default.
• W2076663174 abstract "The molecular mechanisms that enable cyclooxygenase-2 (COX-2) and its mediator prostaglandin E2 (PGE2) to inhibit transforming growth factor-β (TGF-β) signaling during mammary tumorigenesis remain unknown. We show here that TGF-β selectively stimulated the expression of the PGE2 receptor EP2, which increased normal and malignant mammary epithelial cell (MEC) invasion, anchorage-independent growth, and resistance to TGF-β-induced cytostasis. Mechanistically, elevated EP2 expression in normal MECs inhibited the coupling of TGF-β to Smad2/3 activation and plasminogen activator inhibitor-1 (PAI1) expression, while EP2 deficiency in these same MECs augmented Smad2/3 activation and PAI expression stimulated by TGF-β. Along these lines, engineering malignant MECs to lack EP2 expression prevented their growth in soft agar, restored their cytostatic response to TGF-β, decreased their invasiveness in response to TGF-β, and potentiated their activation of Smad2/3 and expression of PAI stimulated by TGF-β. More important, we show that COX-2 or EP2 deficiency both significantly decreased the growth, angiogenesis, and pulmonary metastasis of mammary tumors produced in mice. Collectively, this investigation establishes EP2 as a potent mediator of the anti-TGF-β activities elicited by COX-2/PGE2 in normal and malignant MECs. Our findings also suggest that pharmacological targeting of EP2 receptors may provide new inroads to antagonize the oncogenic activities of TGF-β during mammary tumorigenesis.—Tian, M., Schiemann, W. P. PGE2 receptor EP2 mediates the antagonistic effect of COX-2 on TGF-β signaling during mammary tumorigenesis. FASEB J. 24, 1105–1116 (2010). www.fasebj.org" @default.
• W2076663174 created "2016-06-24" @default.
• W2076663174 creator A5063812000 @default.
• W2076663174 creator A5090145675 @default.
• W2076663174 date "2009-11-06" @default.
• W2076663174 modified "2023-10-18" @default.
• W2076663174 title "PGE2 receptor EP2 mediates the antagonistic effect of COX‐2 on TGF‐β signaling during mammary tumorigenesis" @default.
• W2076663174 cites W1514189093 @default.
• W2076663174 cites W1963685103 @default.
• W2076663174 cites W1966052610 @default.
• W2076663174 cites W1970050679 @default.
• W2076663174 cites W1984031731 @default.
• W2076663174 cites W1987180459 @default.
• W2076663174 cites W1988939737 @default.
• W2076663174 cites W1989810757 @default.
• W2076663174 cites W1994244664 @default.
• W2076663174 cites W1998549100 @default.
• W2076663174 cites W2006139657 @default.
• W2076663174 cites W2016443777 @default.
• W2076663174 cites W2017816682 @default.
• W2076663174 cites W2024579029 @default.
• W2076663174 cites W2028781081 @default.
• W2076663174 cites W2029972069 @default.
• W2076663174 cites W2030607398 @default.
• W2076663174 cites W2034232173 @default.
• W2076663174 cites W2036264501 @default.
• W2076663174 cites W2037038224 @default.
• W2076663174 cites W2041676299 @default.
• W2076663174 cites W2045016464 @default.
• W2076663174 cites W2046693139 @default.
• W2076663174 cites W2049700201 @default.
• W2076663174 cites W2053425043 @default.
• W2076663174 cites W2058034672 @default.
• W2076663174 cites W2063322239 @default.
• W2076663174 cites W2070732038 @default.
• W2076663174 cites W2082833890 @default.
• W2076663174 cites W2087744847 @default.
• W2076663174 cites W2097404490 @default.
• W2076663174 cites W2111769468 @default.
• W2076663174 cites W2115410765 @default.
• W2076663174 cites W2122475546 @default.
• W2076663174 cites W2124836729 @default.
• W2076663174 cites W2129520134 @default.
• W2076663174 cites W2130525687 @default.
• W2076663174 cites W2136237753 @default.
• W2076663174 cites W2137385309 @default.
• W2076663174 cites W2146995890 @default.
• W2076663174 cites W2150560269 @default.
• W2076663174 cites W2151014103 @default.
• W2076663174 cites W2152064969 @default.
• W2076663174 cites W2153476501 @default.
• W2076663174 cites W2158418276 @default.
• W2076663174 cites W2162053625 @default.
• W2076663174 cites W2165046771 @default.
• W2076663174 cites W2165113897 @default.
• W2076663174 cites W2165663767 @default.
• W2076663174 cites W2168051211 @default.
• W2076663174 cites W2396056147 @default.
• W2076663174 doi "https://doi.org/10.1096/fj.09-141341" @default.
• W2076663174 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2845432" @default.
• W2076663174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19897661" @default.
• W2076663174 hasPublicationYear "2009" @default.
• W2076663174 type Work @default.
• W2076663174 sameAs 2076663174 @default.
• W2076663174 citedByCount "58" @default.
• W2076663174 countsByYear W20766631742012 @default.
• W2076663174 countsByYear W20766631742013 @default.
• W2076663174 countsByYear W20766631742014 @default.
• W2076663174 countsByYear W20766631742015 @default.
• W2076663174 countsByYear W20766631742016 @default.
• W2076663174 countsByYear W20766631742017 @default.
• W2076663174 countsByYear W20766631742018 @default.
• W2076663174 countsByYear W20766631742019 @default.
• W2076663174 countsByYear W20766631742020 @default.
• W2076663174 countsByYear W20766631742021 @default.
• W2076663174 countsByYear W20766631742022 @default.
• W2076663174 countsByYear W20766631742023 @default.
• W2076663174 crossrefType "journal-article" @default.
• W2076663174 hasAuthorship W2076663174A5063812000 @default.
• W2076663174 hasAuthorship W2076663174A5090145675 @default.
• W2076663174 hasBestOaLocation W20766631742 @default.
• W2076663174 hasConcept C109316439 @default.
• W2076663174 hasConcept C118131993 @default.
• W2076663174 hasConcept C121608353 @default.
• W2076663174 hasConcept C126322002 @default.
• W2076663174 hasConcept C134018914 @default.
• W2076663174 hasConcept C170493617 @default.
• W2076663174 hasConcept C178592051 @default.
• W2076663174 hasConcept C182547069 @default.
• W2076663174 hasConcept C185592680 @default.
• W2076663174 hasConcept C202751555 @default.
• W2076663174 hasConcept C2107291 @default.
• W2076663174 hasConcept C2776187077 @default.
• W2076663174 hasConcept C2778938600 @default.
• W2076663174 hasConcept C502942594 @default.
• W2076663174 hasConcept C530470458 @default.
• W2076663174 hasConcept C55493867 @default.
• W2076663174 hasConcept C555283112 @default.

• next