FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076665010> ?p ?o ?g. }

• W2076665010 endingPage "14046" @default.
• W2076665010 startingPage "14041" @default.
• W2076665010 abstract "Ndt80 is a transcriptional activator required for meiosis in the yeast Saccharomyces cerevisiae. Here, we report the crystal structure at 2.3 A resolution of the DNA-binding domain of Ndt80 experimentally phased by using the anomalous and isomorphous signal from a single ordered Se atom per molecule of 272-aa residues. The structure reveals a single approximately 32-kDa domain with a distinct fold comprising a beta-sandwich core elaborated with seven additional beta-sheets and three short alpha-helices. Inspired by the structure, we have performed a mutational analysis and defined a DNA-binding motif in this domain. The DNA-binding domain of Ndt80 is homologous to a number of proteins from higher eukaryotes, and the residues that we have shown are required for DNA binding by Ndt80 are highly conserved among this group of proteins. These results suggest that Ndt80 is the defining member of a previously uncharacterized family of transcription factors, including the human protein (C11orf9), which has been shown to be highly expressed in invasive or metastatic tumor cells." @default.
• W2076665010 created "2016-06-24" @default.
• W2076665010 creator A5013003121 @default.
• W2076665010 creator A5017789502 @default.
• W2076665010 creator A5041580310 @default.
• W2076665010 creator A5049878131 @default.
• W2076665010 creator A5068448613 @default.
• W2076665010 creator A5071371374 @default.
• W2076665010 date "2002-10-16" @default.
• W2076665010 modified "2023-09-27" @default.
• W2076665010 title "Crystal structure of the DNA-binding domain from Ndt80, a transcriptional activator required for meiosis in yeast" @default.
• W2076665010 cites W1586722842 @default.
• W2076665010 cites W1591680814 @default.
• W2076665010 cites W1943612516 @default.
• W2076665010 cites W1984823473 @default.
• W2076665010 cites W1993751571 @default.
• W2076665010 cites W1994915896 @default.
• W2076665010 cites W1995017064 @default.
• W2076665010 cites W2009972857 @default.
• W2076665010 cites W2013083986 @default.
• W2076665010 cites W2022058405 @default.
• W2076665010 cites W2028231353 @default.
• W2076665010 cites W2051219295 @default.
• W2076665010 cites W2063473501 @default.
• W2076665010 cites W2078419016 @default.
• W2076665010 cites W2080476827 @default.
• W2076665010 cites W2080528351 @default.
• W2076665010 cites W2094157386 @default.
• W2076665010 cites W2101446086 @default.
• W2076665010 cites W2106315897 @default.
• W2076665010 cites W2106882534 @default.
• W2076665010 cites W2110537583 @default.
• W2076665010 cites W2120038120 @default.
• W2076665010 cites W2135951244 @default.
• W2076665010 cites W2146941705 @default.
• W2076665010 cites W2148066840 @default.
• W2076665010 cites W2148541350 @default.
• W2076665010 cites W2158714788 @default.
• W2076665010 doi "https://doi.org/10.1073/pnas.222312199" @default.
• W2076665010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/137833" @default.
• W2076665010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12384578" @default.
• W2076665010 hasPublicationYear "2002" @default.
• W2076665010 type Work @default.
• W2076665010 sameAs 2076665010 @default.
• W2076665010 citedByCount "38" @default.
• W2076665010 countsByYear W20766650102012 @default.
• W2076665010 countsByYear W20766650102013 @default.
• W2076665010 countsByYear W20766650102016 @default.
• W2076665010 countsByYear W20766650102017 @default.
• W2076665010 countsByYear W20766650102018 @default.
• W2076665010 countsByYear W20766650102019 @default.
• W2076665010 countsByYear W20766650102020 @default.
• W2076665010 crossrefType "journal-article" @default.
• W2076665010 hasAuthorship W2076665010A5013003121 @default.
• W2076665010 hasAuthorship W2076665010A5017789502 @default.
• W2076665010 hasAuthorship W2076665010A5041580310 @default.
• W2076665010 hasAuthorship W2076665010A5049878131 @default.
• W2076665010 hasAuthorship W2076665010A5068448613 @default.
• W2076665010 hasAuthorship W2076665010A5071371374 @default.
• W2076665010 hasBestOaLocation W20766650102 @default.
• W2076665010 hasConcept C104317684 @default.
• W2076665010 hasConcept C138885662 @default.
• W2076665010 hasConcept C167625842 @default.
• W2076665010 hasConcept C179926584 @default.
• W2076665010 hasConcept C185592680 @default.
• W2076665010 hasConcept C2777576037 @default.
• W2076665010 hasConcept C2779222958 @default.
• W2076665010 hasConcept C33987129 @default.
• W2076665010 hasConcept C41895202 @default.
• W2076665010 hasConcept C45484198 @default.
• W2076665010 hasConcept C47701112 @default.
• W2076665010 hasConcept C51639874 @default.
• W2076665010 hasConcept C54355233 @default.
• W2076665010 hasConcept C552990157 @default.
• W2076665010 hasConcept C55493867 @default.
• W2076665010 hasConcept C65556437 @default.
• W2076665010 hasConcept C8010536 @default.
• W2076665010 hasConcept C86339819 @default.
• W2076665010 hasConcept C86803240 @default.
• W2076665010 hasConcept C88045685 @default.
• W2076665010 hasConcept C94966510 @default.
• W2076665010 hasConcept C95444343 @default.
• W2076665010 hasConceptScore W2076665010C104317684 @default.
• W2076665010 hasConceptScore W2076665010C138885662 @default.
• W2076665010 hasConceptScore W2076665010C167625842 @default.
• W2076665010 hasConceptScore W2076665010C179926584 @default.
• W2076665010 hasConceptScore W2076665010C185592680 @default.
• W2076665010 hasConceptScore W2076665010C2777576037 @default.
• W2076665010 hasConceptScore W2076665010C2779222958 @default.
• W2076665010 hasConceptScore W2076665010C33987129 @default.
• W2076665010 hasConceptScore W2076665010C41895202 @default.
• W2076665010 hasConceptScore W2076665010C45484198 @default.
• W2076665010 hasConceptScore W2076665010C47701112 @default.
• W2076665010 hasConceptScore W2076665010C51639874 @default.
• W2076665010 hasConceptScore W2076665010C54355233 @default.
• W2076665010 hasConceptScore W2076665010C552990157 @default.
• W2076665010 hasConceptScore W2076665010C55493867 @default.
• W2076665010 hasConceptScore W2076665010C65556437 @default.

• next