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• W2076665629 startingPage "267" @default.
• W2076665629 abstract "Systemic sclerosis (SSc) is a complex and incompletely understood disease associated with fibrosis in multiple organs. Recent findings identify transforming growth factor-ß (TGF-ß), Wnt ligands, toll-like receptor-mediated signaling, hypoxia, type I interferon, type 2 immune responses and mechanical stress as extracellular cues that modulate fibroblast function and differentiation, and as potential targets for therapy. Moreover, fibrillin-1 has a major role in storing and regulating the bioavailability of TGF-ß and other cytokines, and fibrillin-1 mutations are implicated in a congenital form of scleroderma called stiff skin syndrome. Fibrosis is due not only to the activation of tissue-resident fibroblasts and their transdifferentiation into myofibroblasts, but also the differentiation of bone marrow-derived fibrocytes, and transition of endothelial and epithelial cells, pericytes and adipocytes into activated mesenchymal cells. These responses are modulated by signaling mediators and microRNAs that amplify or inhibit TGF-ß and Wnt signaling. Gain-of-function and loss-of-function abnormalities of these mediators may account for the characteristic activated phenotype of SSc fibroblasts. The nuclear orphan receptor PPAR-γ plays a particularly important role in limiting the duration and intensity of fibroblast activation and differentiation, and impaired PPAR-γ expression or function in SSc may underlie the uncontrolled progression of fibrosis. Identifying the perturbations in signaling pathways, mediators and differentiation programs that are responsible for SSc tissue damage allows their selective targeting. This in turn opens the door for therapies utilizing novel compounds, or drug repurposing by innovative uses of already-approved drugs. In view of the heterogeneous clinical presentation and unpredictable course of SSc, as well as its complex pathogenesis, only robust clinical trials incorporating the judicious application of biomarkers will be able to clarify the clinical utility of these innovative approaches." @default.
• W2076665629 created "2016-06-24" @default.
• W2076665629 creator A5012966437 @default.
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• W2076665629 date "2011-03-01" @default.
• W2076665629 modified "2023-10-18" @default.
• W2076665629 title "Fibrosis in systemic sclerosis: Emerging concepts and implications for targeted therapy" @default.
• W2076665629 cites W1918709511 @default.
• W2076665629 cites W1967803088 @default.
• W2076665629 cites W1970408063 @default.
• W2076665629 cites W1970779494 @default.
• W2076665629 cites W1975275391 @default.
• W2076665629 cites W1975509879 @default.
• W2076665629 cites W1977445008 @default.
• W2076665629 cites W1977956981 @default.
• W2076665629 cites W1984195841 @default.
• W2076665629 cites W1984939059 @default.
• W2076665629 cites W1985414680 @default.
• W2076665629 cites W1987104810 @default.
• W2076665629 cites W1990215671 @default.
• W2076665629 cites W1990218742 @default.
• W2076665629 cites W1994252128 @default.
• W2076665629 cites W1994713876 @default.
• W2076665629 cites W1997010716 @default.
• W2076665629 cites W1998094729 @default.
• W2076665629 cites W2004487653 @default.
• W2076665629 cites W2005403632 @default.
• W2076665629 cites W2009462327 @default.
• W2076665629 cites W2009470034 @default.
• W2076665629 cites W2012580599 @default.
• W2076665629 cites W2015061830 @default.
• W2076665629 cites W2016611373 @default.
• W2076665629 cites W2018833549 @default.
• W2076665629 cites W2025013855 @default.
• W2076665629 cites W2025657436 @default.
• W2076665629 cites W2030725785 @default.
• W2076665629 cites W2032283922 @default.
• W2076665629 cites W2043044541 @default.
• W2076665629 cites W2043691868 @default.
• W2076665629 cites W2045253500 @default.
• W2076665629 cites W2046958946 @default.
• W2076665629 cites W2047406797 @default.
• W2076665629 cites W2051259340 @default.
• W2076665629 cites W2052649367 @default.
• W2076665629 cites W2053470746 @default.
• W2076665629 cites W2054362724 @default.
• W2076665629 cites W2068025507 @default.
• W2076665629 cites W2069775532 @default.
• W2076665629 cites W2076190000 @default.
• W2076665629 cites W2076415587 @default.
• W2076665629 cites W2078853486 @default.
• W2076665629 cites W2080345081 @default.
• W2076665629 cites W2081741824 @default.
• W2076665629 cites W2088743507 @default.
• W2076665629 cites W2089754366 @default.
• W2076665629 cites W2091620221 @default.
• W2076665629 cites W2092490268 @default.
• W2076665629 cites W2093882499 @default.
• W2076665629 cites W2094206799 @default.
• W2076665629 cites W2094596462 @default.
• W2076665629 cites W2099447582 @default.
• W2076665629 cites W2106143687 @default.
• W2076665629 cites W2115279208 @default.
• W2076665629 cites W2115637648 @default.
• W2076665629 cites W2125733524 @default.
• W2076665629 cites W2128573668 @default.
• W2076665629 cites W2131032222 @default.
• W2076665629 cites W2142718675 @default.
• W2076665629 cites W2151163438 @default.
• W2076665629 cites W2153981632 @default.
• W2076665629 cites W2155703015 @default.
• W2076665629 cites W2157101382 @default.
• W2076665629 cites W2164906049 @default.
• W2076665629 cites W2171347998 @default.
• W2076665629 cites W4255749946 @default.
• W2076665629 cites W4255779404 @default.
• W2076665629 doi "https://doi.org/10.1016/j.autrev.2010.09.015" @default.
• W2076665629 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3998379" @default.
• W2076665629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20863909" @default.
• W2076665629 hasPublicationYear "2011" @default.
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