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- W2076665762 abstract "The disposition and metabolism of spironolactone (I), canrenone (II), and potassium canrenoate (III) in dogs were followed by fluorescence methods and by tritium label of I and III. Spironolactone was rapidly converted to nonfluorogenic, possibly reduced, metabolites, which were concentrated in the bile fluid (35% of the dose within 6 hr.). The 4,6-dienone, III, followed a similar metabolic pathway to nonfluorogenic metabolites; however, it was eliminated at a slower rate than I. Urinary excretion was rather low (about 2% of the dose in 6 hr.), and gastric cycling was virtually absent. A preliminary pharmacokinetic model in the dog is suggested. Equimolar amounts of I and II were given perorally and intravenously for absorption studies. The bioavailability to the central compartment was about 40% following oral doses, whereas the absorption amounted to about 80% when judged by the biliary excretion after oral and intravenous doses. The difference is explained by the effective hepatic clearance following oral administration." @default.
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- W2076665762 date "1972-07-01" @default.
- W2076665762 modified "2023-09-27" @default.
- W2076665762 title "Disposition of Tritium-Labeled Spirolactones in the Dog" @default.
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- W2076665762 doi "https://doi.org/10.1002/jps.2600610721" @default.
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