FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076670358> ?p ?o ?g. }

• W2076670358 endingPage "161" @default.
• W2076670358 startingPage "156" @default.
• W2076670358 abstract "Nodal (nodal growth differentiation factor) and its inhibitor Lefty (left right determination factor), which are ligands of the TGF (transforming growth factor) β superfamily, are responsible for the determination of left-right asymmetry in vertebrates. Nodal/Lefty signaling has been suggested to play a role in the development of metastatic melanoma and breast cancer. However, it remains unclear whether this pathway is also involved in human pancreatic ductal adenocarcinoma (PDAC). Pancreatic cancer patient specimens with clinical data (n = 54) were used to investigate the clinical significance of Nodal-Lefty signaling. A set of in vitro assays were carried out in a human pancreatic cancer cell line (Colo-357) to assess the functional relevance of Nodal-Lefty signaling. Nodal was absent in the human normal pancreas, while Lefty was present in islet cells. Though Nodal and Lefty expression were found in cancer cells at various expression levels, the cancer-associated tubular complexes were particularly positive for Lefty. Survival analysis revealed that high expression of Nodal correlated with reduced patient survival (median survival 17.8 vs 33.0 months, p = 0.013). Cultured pancreatic cancer cell lines expressed Nodal and Lefty at different levels. In vitro functional assays revealed that treatment with human recombinant Nodal inhibited cell growth and increased invasion of Colo-357 pancreatic cancer cells whereas no effect was found upon treatment with recombinant Lefty. Nodal-Lefty signaling might be involved in the pathogenesis of PDAC as Nodal expression marks a subtype of PDAC with unfavorable prognosis." @default.
• W2076670358 created "2016-06-24" @default.
• W2076670358 creator A5006574809 @default.
• W2076670358 creator A5031667128 @default.
• W2076670358 creator A5033233301 @default.
• W2076670358 creator A5047932326 @default.
• W2076670358 creator A5063785731 @default.
• W2076670358 creator A5089550509 @default.
• W2076670358 date "2015-03-01" @default.
• W2076670358 modified "2023-10-18" @default.
• W2076670358 title "Increased expression of Nodal correlates with reduced patient survival in pancreatic cancer" @default.
• W2076670358 cites W1976140125 @default.
• W2076670358 cites W1978216398 @default.
• W2076670358 cites W1986829345 @default.
• W2076670358 cites W1987220381 @default.
• W2076670358 cites W1991516094 @default.
• W2076670358 cites W1995027351 @default.
• W2076670358 cites W1995473388 @default.
• W2076670358 cites W2002689737 @default.
• W2076670358 cites W2014691022 @default.
• W2076670358 cites W2016103788 @default.
• W2076670358 cites W2034683528 @default.
• W2076670358 cites W2035131862 @default.
• W2076670358 cites W2054292890 @default.
• W2076670358 cites W2056646351 @default.
• W2076670358 cites W2056927927 @default.
• W2076670358 cites W2061943708 @default.
• W2076670358 cites W2063018805 @default.
• W2076670358 cites W2065546801 @default.
• W2076670358 cites W2066650952 @default.
• W2076670358 cites W2071255863 @default.
• W2076670358 cites W2073264990 @default.
• W2076670358 cites W2087946905 @default.
• W2076670358 cites W2092088384 @default.
• W2076670358 cites W2093750998 @default.
• W2076670358 cites W2094144963 @default.
• W2076670358 cites W2095762981 @default.
• W2076670358 cites W2130821995 @default.
• W2076670358 cites W2131266938 @default.
• W2076670358 cites W2138155367 @default.
• W2076670358 cites W2139805080 @default.
• W2076670358 cites W2143291443 @default.
• W2076670358 cites W2152099298 @default.
• W2076670358 cites W2154568166 @default.
• W2076670358 cites W2156339533 @default.
• W2076670358 cites W2157739976 @default.
• W2076670358 cites W2161949020 @default.
• W2076670358 cites W2169961966 @default.
• W2076670358 cites W2170459912 @default.
• W2076670358 cites W2329693203 @default.
• W2076670358 doi "https://doi.org/10.1016/j.pan.2015.02.001" @default.
• W2076670358 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25708930" @default.
• W2076670358 hasPublicationYear "2015" @default.
• W2076670358 type Work @default.
• W2076670358 sameAs 2076670358 @default.
• W2076670358 citedByCount "19" @default.
• W2076670358 countsByYear W20766703582015 @default.
• W2076670358 countsByYear W20766703582016 @default.
• W2076670358 countsByYear W20766703582017 @default.
• W2076670358 countsByYear W20766703582019 @default.
• W2076670358 countsByYear W20766703582020 @default.
• W2076670358 countsByYear W20766703582021 @default.
• W2076670358 countsByYear W20766703582022 @default.
• W2076670358 crossrefType "journal-article" @default.
• W2076670358 hasAuthorship W2076670358A5006574809 @default.
• W2076670358 hasAuthorship W2076670358A5031667128 @default.
• W2076670358 hasAuthorship W2076670358A5033233301 @default.
• W2076670358 hasAuthorship W2076670358A5047932326 @default.
• W2076670358 hasAuthorship W2076670358A5063785731 @default.
• W2076670358 hasAuthorship W2076670358A5089550509 @default.
• W2076670358 hasConcept C121608353 @default.
• W2076670358 hasConcept C126322002 @default.
• W2076670358 hasConcept C129536746 @default.
• W2076670358 hasConcept C143998085 @default.
• W2076670358 hasConcept C196843134 @default.
• W2076670358 hasConcept C205583638 @default.
• W2076670358 hasConcept C2780210213 @default.
• W2076670358 hasConcept C502942594 @default.
• W2076670358 hasConcept C71924100 @default.
• W2076670358 hasConcept C83330619 @default.
• W2076670358 hasConcept C86803240 @default.
• W2076670358 hasConcept C87073359 @default.
• W2076670358 hasConcept C95444343 @default.
• W2076670358 hasConceptScore W2076670358C121608353 @default.
• W2076670358 hasConceptScore W2076670358C126322002 @default.
• W2076670358 hasConceptScore W2076670358C129536746 @default.
• W2076670358 hasConceptScore W2076670358C143998085 @default.
• W2076670358 hasConceptScore W2076670358C196843134 @default.
• W2076670358 hasConceptScore W2076670358C205583638 @default.
• W2076670358 hasConceptScore W2076670358C2780210213 @default.
• W2076670358 hasConceptScore W2076670358C502942594 @default.
• W2076670358 hasConceptScore W2076670358C71924100 @default.
• W2076670358 hasConceptScore W2076670358C83330619 @default.
• W2076670358 hasConceptScore W2076670358C86803240 @default.
• W2076670358 hasConceptScore W2076670358C87073359 @default.
• W2076670358 hasConceptScore W2076670358C95444343 @default.
• W2076670358 hasIssue "2" @default.
• W2076670358 hasLocation W20766703581 @default.

• next