Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076670467> ?p ?o ?g. }
- W2076670467 endingPage "436" @default.
- W2076670467 startingPage "430" @default.
- W2076670467 abstract "Surfactant protein D (SP-D) is a calcium-dependent carbohydrate-binding protein that is secreted into the pulmonary airspaces by type II epithelial and Clara cells. Previous studies have shown that SP-D can bind to specific surfactant phospholipids and to glycoconjugates associated with the surface of various microorganisms, consistent with possible roles in surfactant metabolism and pulmonary host defense. We now describe specific saccharide-mediated interactions of SP-D with alveolar macrophages in lung tissue and in vitro. Biotinylated rat SP-D showed specific binding to alveolar macrophages in sections of rat lung; this labeling was inhibited by competing saccharides or EDTA. In addition, the binding of 125I-SP-D to isolated alveolar macrophages in the presence of calcium was time-dependent, saturable, and reversible and was preferentially inhibited by known monosaccharide and disaccharide ligands for SP-D. Scatchard analysis gave an apparent single class of binding sites with a Kd = 1.4 x 10(-6) M. We speculate that the multivalent structure of SP-D mediates bridging interactions between microbial glycoconjugates or surfactant phospholipids and specific glycosylated ligands expressed on the surface of phagocytic cells." @default.
- W2076670467 created "2016-06-24" @default.
- W2076670467 creator A5052766444 @default.
- W2076670467 creator A5066276988 @default.
- W2076670467 creator A5077520720 @default.
- W2076670467 creator A5084262435 @default.
- W2076670467 date "1994-04-01" @default.
- W2076670467 modified "2023-10-15" @default.
- W2076670467 title "Lectin-mediated interactions of surfactant protein D with alveolar macrophages." @default.
- W2076670467 cites W1195340218 @default.
- W2076670467 cites W1270417454 @default.
- W2076670467 cites W128701945 @default.
- W2076670467 cites W1487613373 @default.
- W2076670467 cites W1500634278 @default.
- W2076670467 cites W1540332208 @default.
- W2076670467 cites W1573118011 @default.
- W2076670467 cites W1573617710 @default.
- W2076670467 cites W1588736007 @default.
- W2076670467 cites W1761358076 @default.
- W2076670467 cites W1831400781 @default.
- W2076670467 cites W1850807967 @default.
- W2076670467 cites W1871517724 @default.
- W2076670467 cites W1889222490 @default.
- W2076670467 cites W1964871627 @default.
- W2076670467 cites W1976432311 @default.
- W2076670467 cites W1981039437 @default.
- W2076670467 cites W1984469505 @default.
- W2076670467 cites W1987050309 @default.
- W2076670467 cites W1999901481 @default.
- W2076670467 cites W2015594044 @default.
- W2076670467 cites W2021990733 @default.
- W2076670467 cites W2026745476 @default.
- W2076670467 cites W2028286814 @default.
- W2076670467 cites W2033450022 @default.
- W2076670467 cites W2044687104 @default.
- W2076670467 cites W2070894409 @default.
- W2076670467 cites W2072343511 @default.
- W2076670467 cites W2078701949 @default.
- W2076670467 cites W2083355246 @default.
- W2076670467 cites W2102140867 @default.
- W2076670467 cites W2119799948 @default.
- W2076670467 cites W2136212260 @default.
- W2076670467 cites W2154897493 @default.
- W2076670467 cites W2156875612 @default.
- W2076670467 cites W2158620829 @default.
- W2076670467 cites W2165393039 @default.
- W2076670467 cites W2175392934 @default.
- W2076670467 cites W2258559497 @default.
- W2076670467 cites W2400979752 @default.
- W2076670467 cites W2403979980 @default.
- W2076670467 cites W2468617660 @default.
- W2076670467 cites W61484374 @default.
- W2076670467 cites W2739993880 @default.
- W2076670467 doi "https://doi.org/10.1165/ajrcmb.10.4.8136158" @default.
- W2076670467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8136158" @default.
- W2076670467 hasPublicationYear "1994" @default.
- W2076670467 type Work @default.
- W2076670467 sameAs 2076670467 @default.
- W2076670467 citedByCount "72" @default.
- W2076670467 countsByYear W20766704672012 @default.
- W2076670467 countsByYear W20766704672015 @default.
- W2076670467 countsByYear W20766704672016 @default.
- W2076670467 crossrefType "journal-article" @default.
- W2076670467 hasAuthorship W2076670467A5052766444 @default.
- W2076670467 hasAuthorship W2076670467A5066276988 @default.
- W2076670467 hasAuthorship W2076670467A5077520720 @default.
- W2076670467 hasAuthorship W2076670467A5084262435 @default.
- W2076670467 hasConcept C133493029 @default.
- W2076670467 hasConcept C13426554 @default.
- W2076670467 hasConcept C136449434 @default.
- W2076670467 hasConcept C170493617 @default.
- W2076670467 hasConcept C185592680 @default.
- W2076670467 hasConcept C194108754 @default.
- W2076670467 hasConcept C202751555 @default.
- W2076670467 hasConcept C204628709 @default.
- W2076670467 hasConcept C2777438239 @default.
- W2076670467 hasConcept C2778543330 @default.
- W2076670467 hasConcept C2779244956 @default.
- W2076670467 hasConcept C2780758401 @default.
- W2076670467 hasConcept C55493867 @default.
- W2076670467 hasConcept C58226133 @default.
- W2076670467 hasConcept C86803240 @default.
- W2076670467 hasConceptScore W2076670467C133493029 @default.
- W2076670467 hasConceptScore W2076670467C13426554 @default.
- W2076670467 hasConceptScore W2076670467C136449434 @default.
- W2076670467 hasConceptScore W2076670467C170493617 @default.
- W2076670467 hasConceptScore W2076670467C185592680 @default.
- W2076670467 hasConceptScore W2076670467C194108754 @default.
- W2076670467 hasConceptScore W2076670467C202751555 @default.
- W2076670467 hasConceptScore W2076670467C204628709 @default.
- W2076670467 hasConceptScore W2076670467C2777438239 @default.
- W2076670467 hasConceptScore W2076670467C2778543330 @default.
- W2076670467 hasConceptScore W2076670467C2779244956 @default.
- W2076670467 hasConceptScore W2076670467C2780758401 @default.
- W2076670467 hasConceptScore W2076670467C55493867 @default.
- W2076670467 hasConceptScore W2076670467C58226133 @default.
- W2076670467 hasConceptScore W2076670467C86803240 @default.
- W2076670467 hasIssue "4" @default.