Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076670908> ?p ?o ?g. }
- W2076670908 endingPage "3780" @default.
- W2076670908 startingPage "3772" @default.
- W2076670908 abstract "The S100A4(mts1) protein stimulates metastatic spread of tumor cells. An elevated expression of S100A4 is associated with poor prognosis in many human cancers. Dynamics of tumor development were studied in S100A4-deficient mice using grafts of CSML100, highly metastatic mouse mammary carcinoma cells. A significant delay in tumor uptake and decreased tumor incidences were observed in S100A4(-/-) mice compared with the wild-type controls. Moreover, tumors developed in S100A4(-/-) mice never metastasize. Immunohistochemical analyses of these tumors revealed reduced vascularity and abnormal distribution of host-derived stroma cells. Coinjection of CSML100 cells with immortalized S100A4(+/+) fibroblasts partially restored the dynamics of tumor development and the ability to form metastasis. These fibroblasts were characterized by an enhanced motility and invasiveness in comparison with S100A4(-/-) fibroblasts, as well as by the ability to release S100A4 into the tumor environment. Taken together, our results point to a determinative role of host-derived stroma cells expressing S100A4 in tumor progression and metastasis." @default.
- W2076670908 created "2016-06-24" @default.
- W2076670908 creator A5002846957 @default.
- W2076670908 creator A5003023498 @default.
- W2076670908 creator A5012516349 @default.
- W2076670908 creator A5016518267 @default.
- W2076670908 creator A5068188519 @default.
- W2076670908 creator A5071960589 @default.
- W2076670908 creator A5085138721 @default.
- W2076670908 date "2005-05-01" @default.
- W2076670908 modified "2023-10-18" @default.
- W2076670908 title "Suppression of Tumor Development and Metastasis Formation in Mice Lacking the <i>S100A4(mts1)</i> Gene" @default.
- W2076670908 cites W1480357432 @default.
- W2076670908 cites W1503337666 @default.
- W2076670908 cites W1505763719 @default.
- W2076670908 cites W1520425169 @default.
- W2076670908 cites W1656339735 @default.
- W2076670908 cites W173643440 @default.
- W2076670908 cites W1808325789 @default.
- W2076670908 cites W1959606306 @default.
- W2076670908 cites W1967060390 @default.
- W2076670908 cites W1975071038 @default.
- W2076670908 cites W1978082261 @default.
- W2076670908 cites W1985021590 @default.
- W2076670908 cites W1987353833 @default.
- W2076670908 cites W1994003134 @default.
- W2076670908 cites W2001857954 @default.
- W2076670908 cites W2003012091 @default.
- W2076670908 cites W2008714016 @default.
- W2076670908 cites W2012124753 @default.
- W2076670908 cites W2013105546 @default.
- W2076670908 cites W2014927326 @default.
- W2076670908 cites W2018488656 @default.
- W2076670908 cites W2031119028 @default.
- W2076670908 cites W2032511198 @default.
- W2076670908 cites W2035666161 @default.
- W2076670908 cites W2037934610 @default.
- W2076670908 cites W2049666067 @default.
- W2076670908 cites W2050743461 @default.
- W2076670908 cites W2053534299 @default.
- W2076670908 cites W2071507111 @default.
- W2076670908 cites W2077416527 @default.
- W2076670908 cites W2078899029 @default.
- W2076670908 cites W2079594074 @default.
- W2076670908 cites W2087677309 @default.
- W2076670908 cites W2111731443 @default.
- W2076670908 cites W2111852156 @default.
- W2076670908 cites W2123124042 @default.
- W2076670908 cites W2134976853 @default.
- W2076670908 cites W2136055108 @default.
- W2076670908 cites W2141342518 @default.
- W2076670908 cites W2149809213 @default.
- W2076670908 cites W2156872018 @default.
- W2076670908 cites W2169413646 @default.
- W2076670908 cites W4243097335 @default.
- W2076670908 doi "https://doi.org/10.1158/0008-5472.can-04-4510" @default.
- W2076670908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15867373" @default.
- W2076670908 hasPublicationYear "2005" @default.
- W2076670908 type Work @default.
- W2076670908 sameAs 2076670908 @default.
- W2076670908 citedByCount "209" @default.
- W2076670908 countsByYear W20766709082012 @default.
- W2076670908 countsByYear W20766709082013 @default.
- W2076670908 countsByYear W20766709082014 @default.
- W2076670908 countsByYear W20766709082015 @default.
- W2076670908 countsByYear W20766709082016 @default.
- W2076670908 countsByYear W20766709082017 @default.
- W2076670908 countsByYear W20766709082018 @default.
- W2076670908 countsByYear W20766709082019 @default.
- W2076670908 countsByYear W20766709082020 @default.
- W2076670908 countsByYear W20766709082021 @default.
- W2076670908 countsByYear W20766709082022 @default.
- W2076670908 countsByYear W20766709082023 @default.
- W2076670908 crossrefType "journal-article" @default.
- W2076670908 hasAuthorship W2076670908A5002846957 @default.
- W2076670908 hasAuthorship W2076670908A5003023498 @default.
- W2076670908 hasAuthorship W2076670908A5012516349 @default.
- W2076670908 hasAuthorship W2076670908A5016518267 @default.
- W2076670908 hasAuthorship W2076670908A5068188519 @default.
- W2076670908 hasAuthorship W2076670908A5071960589 @default.
- W2076670908 hasAuthorship W2076670908A5085138721 @default.
- W2076670908 hasBestOaLocation W20766709081 @default.
- W2076670908 hasConcept C121608353 @default.
- W2076670908 hasConcept C142724271 @default.
- W2076670908 hasConcept C178596483 @default.
- W2076670908 hasConcept C203014093 @default.
- W2076670908 hasConcept C204232928 @default.
- W2076670908 hasConcept C2776187077 @default.
- W2076670908 hasConcept C2779013556 @default.
- W2076670908 hasConcept C2779256057 @default.
- W2076670908 hasConcept C502942594 @default.
- W2076670908 hasConcept C52124034 @default.
- W2076670908 hasConcept C530470458 @default.
- W2076670908 hasConcept C54355233 @default.
- W2076670908 hasConcept C58207958 @default.
- W2076670908 hasConcept C71924100 @default.
- W2076670908 hasConcept C86803240 @default.
- W2076670908 hasConcept C95444343 @default.