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- W2076672259 endingPage "379" @default.
- W2076672259 startingPage "353" @default.
- W2076672259 abstract "Mathematical modeling and computational analysis are essential for understanding the dynamics of the complex gene networks that control normal development and homeostasis, and can help to understand how circumvention of that control leads to abnormal outcomes such as cancer. Our objectives here are to discuss the different mechanisms by which the local biochemical and mechanical microenvironment, which is comprised of various signaling molecules, cell types and the extracellular matrix (ECM), affects the progression of potentially-cancerous cells, and to present new results on two aspects of these effects. We first deal with the major processes involved in the progression from a normal cell to a cancerous cell at a level accessible to a general scientific readership, and we then outline a number of mathematical and computational issues that arise in cancer modeling. In Section 2 we present results from a model that deals with the effects of the mechanical properties of the environment on tumor growth, and in Section 3 we report results from a model of the signaling pathways and the tumor microenvironment (TME), and how their interactions affect the development of breast cancer. The results emphasize anew the complexities of the interactions within the TME and their effect on tumor growth, and show that tumor progression is not solely determined by the presence of a clone of mutated immortal cells, but rather that it can be ‘community-controlled’." @default.
- W2076672259 created "2016-06-24" @default.
- W2076672259 creator A5026623974 @default.
- W2076672259 creator A5035946182 @default.
- W2076672259 creator A5054877460 @default.
- W2076672259 date "2011-08-01" @default.
- W2076672259 modified "2023-10-02" @default.
- W2076672259 title "The role of the microenvironment in tumor growth and invasion" @default.
- W2076672259 cites W1216615983 @default.
- W2076672259 cites W1502751289 @default.
- W2076672259 cites W1540968669 @default.
- W2076672259 cites W1576773659 @default.
- W2076672259 cites W1969375579 @default.
- W2076672259 cites W1969588976 @default.
- W2076672259 cites W1971386805 @default.
- W2076672259 cites W1971635936 @default.
- W2076672259 cites W1971985588 @default.
- W2076672259 cites W1972429412 @default.
- W2076672259 cites W1973899461 @default.
- W2076672259 cites W1974158461 @default.
- W2076672259 cites W1978139448 @default.
- W2076672259 cites W1978913809 @default.
- W2076672259 cites W1980523198 @default.
- W2076672259 cites W1981827621 @default.
- W2076672259 cites W1981873594 @default.
- W2076672259 cites W1983838379 @default.
- W2076672259 cites W1984096144 @default.
- W2076672259 cites W1987001761 @default.
- W2076672259 cites W1989756070 @default.
- W2076672259 cites W1994373703 @default.
- W2076672259 cites W1996381480 @default.
- W2076672259 cites W2000399084 @default.
- W2076672259 cites W2003325719 @default.
- W2076672259 cites W2004272388 @default.
- W2076672259 cites W2004546130 @default.
- W2076672259 cites W2007044718 @default.
- W2076672259 cites W2009024878 @default.
- W2076672259 cites W2010069724 @default.
- W2076672259 cites W2012124753 @default.
- W2076672259 cites W2013496530 @default.
- W2076672259 cites W2014455063 @default.
- W2076672259 cites W2015962929 @default.
- W2076672259 cites W2020842741 @default.
- W2076672259 cites W2025521327 @default.
- W2076672259 cites W2028001136 @default.
- W2076672259 cites W2034269086 @default.
- W2076672259 cites W2035538295 @default.
- W2076672259 cites W2035653659 @default.
- W2076672259 cites W2043967411 @default.
- W2076672259 cites W2045434770 @default.
- W2076672259 cites W2049387285 @default.
- W2076672259 cites W2052268015 @default.
- W2076672259 cites W2058170745 @default.
- W2076672259 cites W2059583170 @default.
- W2076672259 cites W2059641178 @default.
- W2076672259 cites W2062289724 @default.
- W2076672259 cites W2062656346 @default.
- W2076672259 cites W2063753069 @default.
- W2076672259 cites W2064989764 @default.
- W2076672259 cites W2071027495 @default.
- W2076672259 cites W2071145526 @default.
- W2076672259 cites W2072451938 @default.
- W2076672259 cites W2072827343 @default.
- W2076672259 cites W2073891485 @default.
- W2076672259 cites W2074629755 @default.
- W2076672259 cites W2077495956 @default.
- W2076672259 cites W2078660746 @default.
- W2076672259 cites W2078684128 @default.
- W2076672259 cites W2078769984 @default.
- W2076672259 cites W2079495618 @default.
- W2076672259 cites W2083154803 @default.
- W2076672259 cites W2086244192 @default.
- W2076672259 cites W2086641174 @default.
- W2076672259 cites W2089716875 @default.
- W2076672259 cites W2092207202 @default.
- W2076672259 cites W2092787533 @default.
- W2076672259 cites W2099692224 @default.
- W2076672259 cites W2099915274 @default.
- W2076672259 cites W2101405933 @default.
- W2076672259 cites W2103031848 @default.
- W2076672259 cites W2103543394 @default.
- W2076672259 cites W2103725270 @default.
- W2076672259 cites W2105458906 @default.
- W2076672259 cites W2110769108 @default.
- W2076672259 cites W2111663010 @default.
- W2076672259 cites W2112847494 @default.
- W2076672259 cites W2116549060 @default.
- W2076672259 cites W2116904882 @default.
- W2076672259 cites W2119373499 @default.
- W2076672259 cites W2125644189 @default.
- W2076672259 cites W2127049578 @default.
- W2076672259 cites W2133219974 @default.
- W2076672259 cites W2134709252 @default.
- W2076672259 cites W2135789936 @default.
- W2076672259 cites W2135942163 @default.
- W2076672259 cites W2140417252 @default.
- W2076672259 cites W2142501126 @default.
- W2076672259 cites W2146099965 @default.