Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076673043> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2076673043 endingPage "371" @default.
- W2076673043 startingPage "366" @default.
- W2076673043 abstract "Late-onset Alzheimer’s disease (LOAD) is the most common neurodegenerative disorder, and has a complex etiology. Recently an intronic polymorphism in the ubiquilin 1 gene (UBQLN1) and a particular haplotype was reported to be associated with LOAD. We investigated whether variants in UBQLN1 confer a risk for the disease in 407 Polish LOAD patients and 407 controls. We observed a weak association with the rs2781002 polymorphism, however, contrary to the initial reports, in our group the association was with the A allele. Risk estimation for AA versus GG genotypes showed that the AA genotype is a weak risk factor for AD (OR = 1.8, 95% CI = 1.1–3.1, p = 0.025). This effect was stronger in a group of LOAD patients without APOE4 allele. Haplotype analyses indicate that there is an increase of haplotypes with an A allele in the case group. Also, the specific haplotypes with the A allele that increase AD risk differ between the APOE4-positive and APOE4-negative pools. However, the association observed seems to be driven mostly by rare (<5%) haplotypes. Results suggest a need for additional association studies and in silico analysis of the UBQLN1 locus." @default.
- W2076673043 created "2016-06-24" @default.
- W2076673043 creator A5026199172 @default.
- W2076673043 creator A5026979519 @default.
- W2076673043 creator A5033690455 @default.
- W2076673043 creator A5054011421 @default.
- W2076673043 creator A5062194357 @default.
- W2076673043 creator A5087954178 @default.
- W2076673043 creator A5089218471 @default.
- W2076673043 creator A5090215615 @default.
- W2076673043 date "2008-01-01" @default.
- W2076673043 modified "2023-09-27" @default.
- W2076673043 title "Analysis of <i>UBQLN1</i> Variants in a Polish Alzheimer’s Disease Patient: Control Series" @default.
- W2076673043 cites W1966741769 @default.
- W2076673043 cites W2008114617 @default.
- W2076673043 cites W2023397683 @default.
- W2076673043 cites W2027007018 @default.
- W2076673043 cites W2071172105 @default.
- W2076673043 cites W2079257659 @default.
- W2076673043 cites W2086286256 @default.
- W2076673043 cites W2090430326 @default.
- W2076673043 cites W2100964764 @default.
- W2076673043 cites W2115484612 @default.
- W2076673043 cites W2154441086 @default.
- W2076673043 cites W2155297600 @default.
- W2076673043 cites W2156220037 @default.
- W2076673043 cites W2157403976 @default.
- W2076673043 cites W2169434436 @default.
- W2076673043 doi "https://doi.org/10.1159/000121006" @default.
- W2076673043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18340109" @default.
- W2076673043 hasPublicationYear "2008" @default.
- W2076673043 type Work @default.
- W2076673043 sameAs 2076673043 @default.
- W2076673043 citedByCount "9" @default.
- W2076673043 countsByYear W20766730432013 @default.
- W2076673043 countsByYear W20766730432014 @default.
- W2076673043 crossrefType "journal-article" @default.
- W2076673043 hasAuthorship W2076673043A5026199172 @default.
- W2076673043 hasAuthorship W2076673043A5026979519 @default.
- W2076673043 hasAuthorship W2076673043A5033690455 @default.
- W2076673043 hasAuthorship W2076673043A5054011421 @default.
- W2076673043 hasAuthorship W2076673043A5062194357 @default.
- W2076673043 hasAuthorship W2076673043A5087954178 @default.
- W2076673043 hasAuthorship W2076673043A5089218471 @default.
- W2076673043 hasAuthorship W2076673043A5090215615 @default.
- W2076673043 hasConcept C104317684 @default.
- W2076673043 hasConcept C126322002 @default.
- W2076673043 hasConcept C135763542 @default.
- W2076673043 hasConcept C146304588 @default.
- W2076673043 hasConcept C180754005 @default.
- W2076673043 hasConcept C197754878 @default.
- W2076673043 hasConcept C2779134260 @default.
- W2076673043 hasConcept C37463918 @default.
- W2076673043 hasConcept C502032728 @default.
- W2076673043 hasConcept C54355233 @default.
- W2076673043 hasConcept C71924100 @default.
- W2076673043 hasConcept C84597430 @default.
- W2076673043 hasConcept C86803240 @default.
- W2076673043 hasConceptScore W2076673043C104317684 @default.
- W2076673043 hasConceptScore W2076673043C126322002 @default.
- W2076673043 hasConceptScore W2076673043C135763542 @default.
- W2076673043 hasConceptScore W2076673043C146304588 @default.
- W2076673043 hasConceptScore W2076673043C180754005 @default.
- W2076673043 hasConceptScore W2076673043C197754878 @default.
- W2076673043 hasConceptScore W2076673043C2779134260 @default.
- W2076673043 hasConceptScore W2076673043C37463918 @default.
- W2076673043 hasConceptScore W2076673043C502032728 @default.
- W2076673043 hasConceptScore W2076673043C54355233 @default.
- W2076673043 hasConceptScore W2076673043C71924100 @default.
- W2076673043 hasConceptScore W2076673043C84597430 @default.
- W2076673043 hasConceptScore W2076673043C86803240 @default.
- W2076673043 hasIssue "4" @default.
- W2076673043 hasLocation W20766730431 @default.
- W2076673043 hasLocation W20766730432 @default.
- W2076673043 hasOpenAccess W2076673043 @default.
- W2076673043 hasPrimaryLocation W20766730431 @default.
- W2076673043 hasRelatedWork W1979729701 @default.
- W2076673043 hasRelatedWork W1982749768 @default.
- W2076673043 hasRelatedWork W1995194052 @default.
- W2076673043 hasRelatedWork W2026258702 @default.
- W2076673043 hasRelatedWork W2077216258 @default.
- W2076673043 hasRelatedWork W2084607411 @default.
- W2076673043 hasRelatedWork W2086024908 @default.
- W2076673043 hasRelatedWork W2090368772 @default.
- W2076673043 hasRelatedWork W2155294402 @default.
- W2076673043 hasRelatedWork W4234789023 @default.
- W2076673043 hasVolume "25" @default.
- W2076673043 isParatext "false" @default.
- W2076673043 isRetracted "false" @default.
- W2076673043 magId "2076673043" @default.
- W2076673043 workType "article" @default.