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- W2076677261 abstract "An effective procedure for decontamination of beta-lactam antibiotic residues or contaminants in the pharmaceutical manufacturing environment was investigated. Decontamination with solutions of hydrochloric acid, sodium hydroxide, hydrogen peroxide and hydroxylamine as agents for degradation was assessed. According to the results, the beta-lactam antibiotics were significantly degraded with sodium hydroxide and hydroxylamine. From the structural analysis of the degradation products of a cephem antibiotic, cefpodoxime proxetil, it was found that hydroxylamine degraded the beta-lactam structure under mild conditions, while sodium hydroxide did not. Therefore, hydroxylamine was considered an appropriate decontamination agent for beta-lactam antibiotics." @default.
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- W2076677261 date "2006-01-01" @default.
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- W2076677261 title "An Approach for Decontamination of .BETA.-Lactam Antibiotic Residues or Contaminants in the Pharmaceutical Manufacturing Environment" @default.
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- W2076677261 doi "https://doi.org/10.1248/cpb.54.1340" @default.
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