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- W2076685372 abstract "Abstract The specific activity of choline acetyltransferase, choline kinase, and acetylcholinesterase was measured in ciliary ganglia of chick embryos from 9 days of incubation to hatching. The specific activity of choline acetyltransferase increased eightfold during this period and the activity per cell increased from 29.5 fmol/hr/cell at 9 days to 2428 at hatching. The specific activity of both choline kinase and acetylcholinesterase was highest at 9 days of incubation although the total activity per ganglion increased nearly six- and eightfold, respectively, during the developmental period studied. The specific activity of choline acetyltransferase in the choroid cells was significantly higher than that in the ciliary cells after 16 days of incubation, with values of 767 and 589 μmol/g dry weight/hr, respectively, at 20 days of incubation. When correlated with the morphological and physiological development, the results of this study indicate that relatively low levels of acetylcholine synthetic capacity (29.5 fmol/hr) are sufficient for a functional cholinergic synapse. The major increase in choline acetyltransferase activity parallels synaptic maturation and the establishment of functional connections by the postganglionic neurons with the peripheral field." @default.
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- W2076685372 date "1976-12-01" @default.
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- W2076685372 title "Choline acetyltransferase, choline kinase, and acetylcholinesterase activities during the development of the chick ciliary ganglion" @default.
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- W2076685372 doi "https://doi.org/10.1016/0014-4886(76)90149-7" @default.
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