FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076687480> ?p ?o ?g. }

• W2076687480 endingPage "36" @default.
• W2076687480 startingPage "29" @default.
• W2076687480 abstract "2-arachidonyl glycerol (2-AG) allosterically potentiates GABA(A) receptors via a binding site located in transmembrane segment M4 of the β₂ subunit. Two amino acid residues have been described that are essential for this effect. With the aim to further describe this potential drug target, we performed a cysteine scanning of the entire M4 and part of M3. All four residues in M4 affecting the potentiation here and the two already identified residues locate to the same side of the α-helix. This side is exposed to M3, where further residues were identified. From the fact that the important residues span > 18 Å, we conclude that the hydrophobic tail of the bound 2-AG molecule must be near linear and that the site mainly locates to the inner leaflet but stretches far into the membrane. The influence of the structure of the head group of the ligand molecule on the activity of the molecule was also investigated. We present a model of 2-AG docked to the GABA(A) receptor." @default.
• W2076687480 created "2016-06-24" @default.
• W2076687480 creator A5000466780 @default.
• W2076687480 creator A5003466681 @default.
• W2076687480 creator A5006031524 @default.
• W2076687480 creator A5034050688 @default.
• W2076687480 creator A5052935578 @default.
• W2076687480 creator A5064366606 @default.
• W2076687480 date "2013-05-03" @default.
• W2076687480 modified "2023-10-12" @default.
• W2076687480 title "Molecular analysis of the site for 2-arachidonylglycerol (2-AG) on the β₂ subunit of GABA_A receptors" @default.
• W2076687480 cites W1482497049 @default.
• W2076687480 cites W1684501056 @default.
• W2076687480 cites W1948082071 @default.
• W2076687480 cites W1965670539 @default.
• W2076687480 cites W1979259053 @default.
• W2076687480 cites W1986750483 @default.
• W2076687480 cites W1991847312 @default.
• W2076687480 cites W1996339077 @default.
• W2076687480 cites W2006367499 @default.
• W2076687480 cites W2022378061 @default.
• W2076687480 cites W2068375642 @default.
• W2076687480 cites W2074631079 @default.
• W2076687480 cites W2085451507 @default.
• W2076687480 cites W2086126018 @default.
• W2076687480 cites W2086547360 @default.
• W2076687480 cites W2099883420 @default.
• W2076687480 cites W2115317881 @default.
• W2076687480 cites W2137471600 @default.
• W2076687480 cites W2176076159 @default.
• W2076687480 doi "https://doi.org/10.1111/jnc.12270" @default.
• W2076687480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23600744" @default.
• W2076687480 hasPublicationYear "2013" @default.
• W2076687480 type Work @default.
• W2076687480 sameAs 2076687480 @default.
• W2076687480 citedByCount "25" @default.
• W2076687480 countsByYear W20766874802013 @default.
• W2076687480 countsByYear W20766874802014 @default.
• W2076687480 countsByYear W20766874802015 @default.
• W2076687480 countsByYear W20766874802016 @default.
• W2076687480 countsByYear W20766874802017 @default.
• W2076687480 countsByYear W20766874802018 @default.
• W2076687480 countsByYear W20766874802022 @default.
• W2076687480 crossrefType "journal-article" @default.
• W2076687480 hasAuthorship W2076687480A5000466780 @default.
• W2076687480 hasAuthorship W2076687480A5003466681 @default.
• W2076687480 hasAuthorship W2076687480A5006031524 @default.
• W2076687480 hasAuthorship W2076687480A5034050688 @default.
• W2076687480 hasAuthorship W2076687480A5052935578 @default.
• W2076687480 hasAuthorship W2076687480A5064366606 @default.
• W2076687480 hasBestOaLocation W20766874801 @default.
• W2076687480 hasConcept C104292427 @default.
• W2076687480 hasConcept C104317684 @default.
• W2076687480 hasConcept C107824862 @default.
• W2076687480 hasConcept C116569031 @default.
• W2076687480 hasConcept C118892022 @default.
• W2076687480 hasConcept C12554922 @default.
• W2076687480 hasConcept C166342909 @default.
• W2076687480 hasConcept C168258287 @default.
• W2076687480 hasConcept C170493617 @default.
• W2076687480 hasConcept C178790620 @default.
• W2076687480 hasConcept C181199279 @default.
• W2076687480 hasConcept C185592680 @default.
• W2076687480 hasConcept C18903297 @default.
• W2076687480 hasConcept C24530287 @default.
• W2076687480 hasConcept C2778530040 @default.
• W2076687480 hasConcept C2779201268 @default.
• W2076687480 hasConcept C2779965526 @default.
• W2076687480 hasConcept C32909587 @default.
• W2076687480 hasConcept C55493867 @default.
• W2076687480 hasConcept C71240020 @default.
• W2076687480 hasConcept C86803240 @default.
• W2076687480 hasConceptScore W2076687480C104292427 @default.
• W2076687480 hasConceptScore W2076687480C104317684 @default.
• W2076687480 hasConceptScore W2076687480C107824862 @default.
• W2076687480 hasConceptScore W2076687480C116569031 @default.
• W2076687480 hasConceptScore W2076687480C118892022 @default.
• W2076687480 hasConceptScore W2076687480C12554922 @default.
• W2076687480 hasConceptScore W2076687480C166342909 @default.
• W2076687480 hasConceptScore W2076687480C168258287 @default.
• W2076687480 hasConceptScore W2076687480C170493617 @default.
• W2076687480 hasConceptScore W2076687480C178790620 @default.
• W2076687480 hasConceptScore W2076687480C181199279 @default.
• W2076687480 hasConceptScore W2076687480C185592680 @default.
• W2076687480 hasConceptScore W2076687480C18903297 @default.
• W2076687480 hasConceptScore W2076687480C24530287 @default.
• W2076687480 hasConceptScore W2076687480C2778530040 @default.
• W2076687480 hasConceptScore W2076687480C2779201268 @default.
• W2076687480 hasConceptScore W2076687480C2779965526 @default.
• W2076687480 hasConceptScore W2076687480C32909587 @default.
• W2076687480 hasConceptScore W2076687480C55493867 @default.
• W2076687480 hasConceptScore W2076687480C71240020 @default.
• W2076687480 hasConceptScore W2076687480C86803240 @default.
• W2076687480 hasFunder F4320320924 @default.
• W2076687480 hasIssue "1" @default.
• W2076687480 hasLocation W20766874801 @default.
• W2076687480 hasLocation W20766874802 @default.
• W2076687480 hasOpenAccess W2076687480 @default.

• next