FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076692085> ?p ?o ?g. }

• W2076692085 abstract "TMEM18 is a hypothalamic gene that has recently been linked to obesity and BMI in genome wide association studies. However, the functional properties of TMEM18 are obscure.The evolutionary history of TMEM18 was inferred using phylogenetic and bioinformatic methods. The gene's expression profile was investigated with real-time PCR in a panel of rat and mouse tissues and with immunohistochemistry in the mouse brain. Also, gene expression changes were analyzed in three feeding-related mouse models: food deprivation, reward and diet-induced increase in body weight. Finally, we genotyped 502 severely obese and 527 healthy Swedish children for two SNPs near TMEM18 (rs6548238 and rs756131).TMEM18 was found to be remarkably conserved and present in species that diverged from the human lineage over 1500 million years ago. The TMEM18 gene was widely expressed and detected in the majority of cells in all major brain regions, but was more abundant in neurons than other cell types. We found no significant changes in the hypothalamic and brainstem expression in the feeding-related mouse models. There was a strong association for two SNPs (rs6548238 and rs756131) of the TMEM18 locus with an increased risk for obesity (p = 0.001 and p = 0.002).We conclude that TMEM18 is involved in both adult and childhood obesity. It is one of the most conserved human obesity genes and it is found in the majority of all brain sites, including the hypothalamus and the brain stem, but it is not regulated in these regions in classical energy homeostatic models." @default.
• W2076692085 created "2016-06-24" @default.
• W2076692085 creator A5005612634 @default.
• W2076692085 creator A5016165622 @default.
• W2076692085 creator A5019947167 @default.
• W2076692085 creator A5034318445 @default.
• W2076692085 creator A5035256429 @default.
• W2076692085 creator A5039005727 @default.
• W2076692085 creator A5047472678 @default.
• W2076692085 creator A5055375727 @default.
• W2076692085 creator A5059419357 @default.
• W2076692085 creator A5073290917 @default.
• W2076692085 creator A5085396890 @default.
• W2076692085 date "2010-04-09" @default.
• W2076692085 modified "2023-10-14" @default.
• W2076692085 title "The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children" @default.
• W2076692085 cites W1511560710 @default.
• W2076692085 cites W1546792714 @default.
• W2076692085 cites W1769768807 @default.
• W2076692085 cites W1981121263 @default.
• W2076692085 cites W1993827187 @default.
• W2076692085 cites W1996423252 @default.
• W2076692085 cites W2016774526 @default.
• W2076692085 cites W2022590250 @default.
• W2076692085 cites W2029082055 @default.
• W2076692085 cites W2038163496 @default.
• W2076692085 cites W2041612616 @default.
• W2076692085 cites W2044892321 @default.
• W2076692085 cites W2062403533 @default.
• W2076692085 cites W2072470496 @default.
• W2076692085 cites W2074231493 @default.
• W2076692085 cites W2081827165 @default.
• W2076692085 cites W2083539491 @default.
• W2076692085 cites W2092207134 @default.
• W2076692085 cites W2092625960 @default.
• W2076692085 cites W2097142998 @default.
• W2076692085 cites W2097660065 @default.
• W2076692085 cites W2101968184 @default.
• W2076692085 cites W2119362018 @default.
• W2076692085 cites W2120772351 @default.
• W2076692085 cites W2127461248 @default.
• W2076692085 cites W2129150286 @default.
• W2076692085 cites W2129775611 @default.
• W2076692085 cites W2131871062 @default.
• W2076692085 cites W2140675235 @default.
• W2076692085 cites W2145573696 @default.
• W2076692085 cites W2151831732 @default.
• W2076692085 cites W2153452535 @default.
• W2076692085 cites W2155471967 @default.
• W2076692085 cites W2158623906 @default.
• W2076692085 cites W2161633633 @default.
• W2076692085 cites W2163144326 @default.
• W2076692085 cites W2164682888 @default.
• W2076692085 cites W2168402785 @default.
• W2076692085 cites W2168696662 @default.
• W2076692085 cites W4210430020 @default.
• W2076692085 cites W4211000692 @default.
• W2076692085 doi "https://doi.org/10.1186/1471-2350-11-58" @default.
• W2076692085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2858727" @default.
• W2076692085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20380707" @default.
• W2076692085 hasPublicationYear "2010" @default.
• W2076692085 type Work @default.
• W2076692085 sameAs 2076692085 @default.
• W2076692085 citedByCount "67" @default.
• W2076692085 countsByYear W20766920852012 @default.
• W2076692085 countsByYear W20766920852013 @default.
• W2076692085 countsByYear W20766920852014 @default.
• W2076692085 countsByYear W20766920852015 @default.
• W2076692085 countsByYear W20766920852016 @default.
• W2076692085 countsByYear W20766920852017 @default.
• W2076692085 countsByYear W20766920852018 @default.
• W2076692085 countsByYear W20766920852019 @default.
• W2076692085 countsByYear W20766920852020 @default.
• W2076692085 countsByYear W20766920852021 @default.
• W2076692085 countsByYear W20766920852022 @default.
• W2076692085 countsByYear W20766920852023 @default.
• W2076692085 crossrefType "journal-article" @default.
• W2076692085 hasAuthorship W2076692085A5005612634 @default.
• W2076692085 hasAuthorship W2076692085A5016165622 @default.
• W2076692085 hasAuthorship W2076692085A5019947167 @default.
• W2076692085 hasAuthorship W2076692085A5034318445 @default.
• W2076692085 hasAuthorship W2076692085A5035256429 @default.
• W2076692085 hasAuthorship W2076692085A5039005727 @default.
• W2076692085 hasAuthorship W2076692085A5047472678 @default.
• W2076692085 hasAuthorship W2076692085A5055375727 @default.
• W2076692085 hasAuthorship W2076692085A5059419357 @default.
• W2076692085 hasAuthorship W2076692085A5073290917 @default.
• W2076692085 hasAuthorship W2076692085A5085396890 @default.
• W2076692085 hasBestOaLocation W20766920851 @default.
• W2076692085 hasConcept C104317684 @default.
• W2076692085 hasConcept C134018914 @default.
• W2076692085 hasConcept C135763542 @default.
• W2076692085 hasConcept C153209595 @default.
• W2076692085 hasConcept C2779422640 @default.
• W2076692085 hasConcept C2780586474 @default.
• W2076692085 hasConcept C511355011 @default.
• W2076692085 hasConcept C54355233 @default.
• W2076692085 hasConcept C84597430 @default.
• W2076692085 hasConcept C86803240 @default.
• W2076692085 hasConceptScore W2076692085C104317684 @default.

• next