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• W2076693792 abstract "Seventy subjects with either no, mild, or definite evidence of pulmonary abnormality on screening studies volunteered to have detailed pulmonary function tests (PFTs), respiratory questionnaires, physical examinations, and 113m indium aerosol-inhalation lung imaging performed. Also, 22 and 52 of these subjects underwent 133 xenon ventilation and lung perfusion imaging with 99m technetium-labelled macroaggregated albumin, and 56 had chest x-ray examinations performed. Results of the radionuclide lung-imaging procedures were compared with those of conventional PFTs and other clinical diagnostic procedures used to identify chronic obstructive pulmonary disease (COPD). Abnormal radioaerosol patterns were found in 32 of 33 subjects with abnormal findings on PFTs, whereas results of PFTs were abnormal in only 32 of 46 subjects with abnormal aerosol deposition. Aerosol lung images were abnormal more frequently than respiratory questionnaire responses, findings on physical examination, chest x-ray films, and perfusion lung images and with approximately the same frequency as 133 xenon ventilation scintiscans. These results suggest that radioaerosol lung imaging may be a more sensitive indicator of early COPD than other diagnostic procedures, including maximal midexpiratory flow rates, single-breath nitrogen washout, and closing volume. Further studies are required to determine the physiologic and pathologic significance of isolated aerosol lung-imaging abnormalities." @default.
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• W2076693792 date "1975-11-01" @default.
• W2076693792 modified "2023-09-24" @default.
• W2076693792 title "Radioaerosol Lung Imaging in Chronic Obstructive Pulmonary Disease" @default.
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• W2076693792 doi "https://doi.org/10.1378/chest.68.5.634" @default.
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