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- W2076697185 abstract "A number of patients with severe aortic valve stenosis (AS) as defined on the basis of aortic valve area (AVA) have low transvalvular gradient. When associated with a reduced left ventricular ejection fraction (LVEF), this condition is called low flow-low gradient AS [ [1] Nishimura R.A. Grantham J.A. Connolly H.M. Schaff H.V. Higano S.T. Holmes D.R. Low-output, low-gradient aortic stenosis in patients with depressed left ventricular systolic function: the clinical utility of the dobutamine challenge in the catheterization laboratory. Circulation. 2002; 106: 809-813 Crossref PubMed Scopus (262) Google Scholar ]. Since gradient measurement is flow dependent, decreased LVEF may explain the low gradient. Nevertheless, low gradient severe AS can be associated also with preserved LVEF. Management of this subgroup of patients is controversial because of the limited amount of data on its prevalence, natural history and outcome after aortic valve replacement (AVR) [ 2 Minners J. Allgeier M. Gohlke-Baerwolf C. et al. Inconsistencies of echocardiographic criteria for the grading of aortic valve stenosis. Eur Heart J. 2008; 29: 1043-1048 Crossref PubMed Scopus (268) Google Scholar , 3 Hachicha Z. Dumesnil J. Bogaty P. Pibarot P. Paradoxical low-flow, low-gradient severe aortic stenosis despite preserved ejection fraction is associated with higher afterload and reduced survival. Circulation. 2007; 115: 2856-2864 Crossref PubMed Scopus (696) Google Scholar ]. We sought to investigate these issues in this study." @default.
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- W2076697185 date "2013-10-01" @default.
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- W2076697185 title "Meta-analysis of the outcome of patients with low gradient severe aortic stenosis and preserved left ventricular ejection fraction" @default.
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- W2076697185 doi "https://doi.org/10.1016/j.ijcard.2013.07.193" @default.
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