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- W2076702607 abstract "Uptake to seven neutral amino acids by rat small intestine during 60 min incubations is presented as a function of position along intestine. There was considerable variation from one amino acid to another in the shape of the uptake curves. The two extremes were the uptake patterns of l-methiomine and betaine. These two patterns were sufficiently different from each other to provide new and independent evidence for the existence of two systems for the transport of neutral amino acids. These transport systems are here called N1 and N2; they are apparently distributed somewhat differently along rat intestine. Uptake patterns for the other amino acids studied (l-leucine, l-alanine, l-proline, glycine and α-aminoisobutyric acid) were between those for methionine and betaine. This situation would be expected if leucine, alanine, proline, glycine and α-aminoisobutyric acid were transported by both N1 and N2. By competitively excluding proline from N1 by adding methionine, it was possible to shift the uptake pattern of proline toward that of betaine. This result adds further support to the idea that proline is transported by both N1 and N2. The converse experiment — shifting the uptake pattern of proline toward that of methionine by adding betaine — was not successful, probably because betaine had a stimulatory effect on proline uptake." @default.
- W2076702607 created "2016-06-24" @default.
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- W2076702607 date "1971-02-01" @default.
- W2076702607 modified "2023-10-18" @default.
- W2076702607 title "Patterns of neutral amino acid uptake along rat small intestine" @default.
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- W2076702607 doi "https://doi.org/10.1016/0005-2736(71)90225-2" @default.
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