Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076707949> ?p ?o ?g. }
- W2076707949 endingPage "273" @default.
- W2076707949 startingPage "265" @default.
- W2076707949 abstract "Neonatal exposure to intermittent hypoxia results in altered ventilatory response to subsequent hypoxia in animal models. The effect of similar exposure in human infants is unknown. Our objective was to determine the impact of sleep disordered breathing (SDB) in early infancy on ventilatory response in infants. We recruited consecutive infants with cleft lip and/or palate (CL/P) to undergo ventilatory response testing using exposure to a hypoxic (15% O2) gas mixture during sleep. This population is at high risk of SDB because of smaller airway caliber and abnormal palatal muscle attachments predisposing them to airway obstruction of ranging severity from birth. Ventilatory responses were compared between infants with a low apnea–hypopnea index (AHI; AHI < 15 events/hr) and a high AHI (AHI ≥ 15 events/hr). Testing was successfully completed in 22 of 23 infants who underwent testing at 4.4 ± 4.8 months. Infants with high AHI had lower weight z-scores, higher number of oxygen desaturation events during sleep, but similar oxygen saturation (SpO2) nadir compared to infants with low AHI. The pattern of ventilatory response to hypoxia differed between the two groups; infants with high AHI had an earlier ventilatory decline and a blunted maximal ventilatory response to hypoxia. Infants with a high AHI use a different strategy to augment ventilation in response to hypoxia; while infants with a low AHI initially increased respiratory rate, tidal volume was the first parameter to increase in infants with high AHI. These results demonstrate that SDB in infancy is associated with altered ventilatory response to hypoxia. Pediatr Pulmonol. 2013; 48:265–273. © 2012 Wiley Periodicals, Inc." @default.
- W2076707949 created "2016-06-24" @default.
- W2076707949 creator A5023184639 @default.
- W2076707949 creator A5045775740 @default.
- W2076707949 creator A5062532134 @default.
- W2076707949 creator A5071449057 @default.
- W2076707949 date "2012-04-23" @default.
- W2076707949 modified "2023-09-24" @default.
- W2076707949 title "Assessing ventilatory control in infants at high risk of sleep disordered breathing: A study of infants with cleft lip and/or palate" @default.
- W2076707949 cites W17595264 @default.
- W2076707949 cites W1965864775 @default.
- W2076707949 cites W1966391498 @default.
- W2076707949 cites W1970965700 @default.
- W2076707949 cites W1970998841 @default.
- W2076707949 cites W1977126154 @default.
- W2076707949 cites W1981412748 @default.
- W2076707949 cites W1988125538 @default.
- W2076707949 cites W1989866034 @default.
- W2076707949 cites W1991947758 @default.
- W2076707949 cites W1997189005 @default.
- W2076707949 cites W1998109800 @default.
- W2076707949 cites W1999772583 @default.
- W2076707949 cites W2000611117 @default.
- W2076707949 cites W2001174872 @default.
- W2076707949 cites W2002620381 @default.
- W2076707949 cites W2010909124 @default.
- W2076707949 cites W2011791335 @default.
- W2076707949 cites W2011827926 @default.
- W2076707949 cites W2020545301 @default.
- W2076707949 cites W2021541323 @default.
- W2076707949 cites W2042137713 @default.
- W2076707949 cites W2042385267 @default.
- W2076707949 cites W2046326059 @default.
- W2076707949 cites W2046702675 @default.
- W2076707949 cites W2046724926 @default.
- W2076707949 cites W2048870600 @default.
- W2076707949 cites W2049295800 @default.
- W2076707949 cites W2051780600 @default.
- W2076707949 cites W2058463290 @default.
- W2076707949 cites W2059546190 @default.
- W2076707949 cites W2061198598 @default.
- W2076707949 cites W2081282232 @default.
- W2076707949 cites W2082068533 @default.
- W2076707949 cites W2084106185 @default.
- W2076707949 cites W2086572358 @default.
- W2076707949 cites W2094003461 @default.
- W2076707949 cites W2096831430 @default.
- W2076707949 cites W2103030537 @default.
- W2076707949 cites W2126576822 @default.
- W2076707949 cites W2135299483 @default.
- W2076707949 cites W2140116729 @default.
- W2076707949 cites W2145438871 @default.
- W2076707949 cites W2150656559 @default.
- W2076707949 cites W2161588730 @default.
- W2076707949 cites W2162533225 @default.
- W2076707949 cites W2164865934 @default.
- W2076707949 cites W2165014191 @default.
- W2076707949 cites W2173972944 @default.
- W2076707949 cites W2229889288 @default.
- W2076707949 cites W2263824030 @default.
- W2076707949 cites W2413135824 @default.
- W2076707949 cites W2471941104 @default.
- W2076707949 cites W25346943 @default.
- W2076707949 cites W4235224076 @default.
- W2076707949 cites W4254890927 @default.
- W2076707949 cites W51269291 @default.
- W2076707949 cites W86149107 @default.
- W2076707949 doi "https://doi.org/10.1002/ppul.22568" @default.
- W2076707949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22528960" @default.
- W2076707949 hasPublicationYear "2012" @default.
- W2076707949 type Work @default.
- W2076707949 sameAs 2076707949 @default.
- W2076707949 citedByCount "9" @default.
- W2076707949 countsByYear W20767079492016 @default.
- W2076707949 countsByYear W20767079492017 @default.
- W2076707949 countsByYear W20767079492020 @default.
- W2076707949 countsByYear W20767079492021 @default.
- W2076707949 countsByYear W20767079492022 @default.
- W2076707949 countsByYear W20767079492023 @default.
- W2076707949 crossrefType "journal-article" @default.
- W2076707949 hasAuthorship W2076707949A5023184639 @default.
- W2076707949 hasAuthorship W2076707949A5045775740 @default.
- W2076707949 hasAuthorship W2076707949A5062532134 @default.
- W2076707949 hasAuthorship W2076707949A5071449057 @default.
- W2076707949 hasConcept C105922876 @default.
- W2076707949 hasConcept C126322002 @default.
- W2076707949 hasConcept C127413603 @default.
- W2076707949 hasConcept C178790620 @default.
- W2076707949 hasConcept C185592680 @default.
- W2076707949 hasConcept C200457457 @default.
- W2076707949 hasConcept C2776006263 @default.
- W2076707949 hasConcept C2777711342 @default.
- W2076707949 hasConcept C2778205975 @default.
- W2076707949 hasConcept C2778333281 @default.
- W2076707949 hasConcept C2780157289 @default.
- W2076707949 hasConcept C2780595715 @default.
- W2076707949 hasConcept C2781326671 @default.
- W2076707949 hasConcept C2908647359 @default.