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- W2076712912 abstract "Significance Although ALS is a motor neuron disease, processes within glial cells contribute significantly to motor neuron-specific degeneration. Using a mouse model of ALS, we identified cell autonomous and nonautonomous changes in gene expression in motor neurons cocultured with glia. We also found a remarkable concordance between the cell culture data and expression profiles of whole spinal cords and acutely isolated spinal cord cells during disease progression in this model. We identified changes in the expression of specific genes and signaling pathways that may contribute to motor neuron degeneration in ALS, among which are TGF-β signaling pathways." @default.
- W2076712912 created "2016-06-24" @default.
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- W2076712912 date "2013-02-06" @default.
- W2076712912 modified "2023-10-01" @default.
- W2076712912 title "Intricate interplay between astrocytes and motor neurons in ALS" @default.
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- W2076712912 doi "https://doi.org/10.1073/pnas.1222361110" @default.
- W2076712912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3581928" @default.
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