Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076715293> ?p ?o ?g. }
- W2076715293 endingPage "108" @default.
- W2076715293 startingPage "95" @default.
- W2076715293 abstract "Retinopathy is one of the commonest microvascular complications of diabetes and is still the prevailing cause of registerable blindness in the working population of developed countries. The clinicopathology of microvascular lesions and the dysregulation of an array of biochemical pathways in the diabetic retina have been extensively studied, although the relative contribution of various biochemical sequelae of hyperglycaemia remains ill- defined. There is little doubt that the pathogenesis of this diabetic complication is highly complex and there is a pressing need to establish new therapeutic regimens that can effectively prevent or retard the initiation and progression of retinal microvascular cell dysfunction and death which is characteristic of the vasodegenerative stages of diabetic retinopathy. Among the several pathogenic mechanisms that may contribute to diabetic retinopathy are the formation and accumulation of advanced glycation endproducts (AGEs). AGEs can form on the amino groups of proteins, lipids, and DNA through a number of complex pathways, including nonenzymatic glycation by glucose and reaction with metabolic intermediates and reactive dicarbonyl intermediates. These reactions not only modify the structure and function of proteins, but also cause intramolecular and intermolecular cross-link formation. AGEs are known to accumulate in the diabetic retina where they may have important effects on retinal vascular cell function in vitro and in vivo. Evidence now points toward a pathogenic role for advanced glycation in the initiation and progression of diabetic retinopathy. This review will examine the basis of AGE-related pathology in the diabetic retina at cellular and molecular levels. It will also outline how recent strategies to inhibit AGE formation or limit their pathogenic influence during chronic diabetes may have an important role to play in the treatment of retinopathy." @default.
- W2076715293 created "2016-06-24" @default.
- W2076715293 creator A5025321891 @default.
- W2076715293 date "2003-08-01" @default.
- W2076715293 modified "2023-10-02" @default.
- W2076715293 title "The role of advanced glycation in the pathogenesis of diabetic retinopathy" @default.
- W2076715293 cites W1529592271 @default.
- W2076715293 cites W1609735481 @default.
- W2076715293 cites W1752750900 @default.
- W2076715293 cites W1825417295 @default.
- W2076715293 cites W1964124333 @default.
- W2076715293 cites W1964628601 @default.
- W2076715293 cites W1964911695 @default.
- W2076715293 cites W1966596942 @default.
- W2076715293 cites W1966941545 @default.
- W2076715293 cites W1968003131 @default.
- W2076715293 cites W1968412917 @default.
- W2076715293 cites W1968625953 @default.
- W2076715293 cites W1972769687 @default.
- W2076715293 cites W1973444933 @default.
- W2076715293 cites W1975145708 @default.
- W2076715293 cites W1976566920 @default.
- W2076715293 cites W1978996756 @default.
- W2076715293 cites W1981614795 @default.
- W2076715293 cites W1986469317 @default.
- W2076715293 cites W1987345610 @default.
- W2076715293 cites W1988591283 @default.
- W2076715293 cites W1990644905 @default.
- W2076715293 cites W1991427290 @default.
- W2076715293 cites W1991592077 @default.
- W2076715293 cites W1991635343 @default.
- W2076715293 cites W1991683975 @default.
- W2076715293 cites W1992152917 @default.
- W2076715293 cites W1992592000 @default.
- W2076715293 cites W1995363602 @default.
- W2076715293 cites W1995428435 @default.
- W2076715293 cites W1997609683 @default.
- W2076715293 cites W1998462777 @default.
- W2076715293 cites W1998498936 @default.
- W2076715293 cites W1998606727 @default.
- W2076715293 cites W2000663727 @default.
- W2076715293 cites W2002705517 @default.
- W2076715293 cites W2005451208 @default.
- W2076715293 cites W2005482739 @default.
- W2076715293 cites W2006104786 @default.
- W2076715293 cites W2007804077 @default.
- W2076715293 cites W2010110541 @default.
- W2076715293 cites W2011500110 @default.
- W2076715293 cites W2011955651 @default.
- W2076715293 cites W2012415352 @default.
- W2076715293 cites W2012945186 @default.
- W2076715293 cites W2013633841 @default.
- W2076715293 cites W2013730613 @default.
- W2076715293 cites W2017391549 @default.
- W2076715293 cites W2018555496 @default.
- W2076715293 cites W2019656247 @default.
- W2076715293 cites W2020985397 @default.
- W2076715293 cites W2021976201 @default.
- W2076715293 cites W2024416898 @default.
- W2076715293 cites W2025543710 @default.
- W2076715293 cites W2025748287 @default.
- W2076715293 cites W2026703782 @default.
- W2076715293 cites W2026753191 @default.
- W2076715293 cites W2031504244 @default.
- W2076715293 cites W2032055976 @default.
- W2076715293 cites W2034363142 @default.
- W2076715293 cites W2034454591 @default.
- W2076715293 cites W2040758881 @default.
- W2076715293 cites W2041012283 @default.
- W2076715293 cites W2041416461 @default.
- W2076715293 cites W2043700489 @default.
- W2076715293 cites W2045310089 @default.
- W2076715293 cites W2045777663 @default.
- W2076715293 cites W2047964022 @default.
- W2076715293 cites W2051108627 @default.
- W2076715293 cites W2051370085 @default.
- W2076715293 cites W2052059287 @default.
- W2076715293 cites W2052963492 @default.
- W2076715293 cites W2053615344 @default.
- W2076715293 cites W2057611314 @default.
- W2076715293 cites W2057628634 @default.
- W2076715293 cites W2058537448 @default.
- W2076715293 cites W2062845551 @default.
- W2076715293 cites W2063051902 @default.
- W2076715293 cites W2063165518 @default.
- W2076715293 cites W2063284869 @default.
- W2076715293 cites W2066512884 @default.
- W2076715293 cites W2068793587 @default.
- W2076715293 cites W2072304282 @default.
- W2076715293 cites W2072434842 @default.
- W2076715293 cites W2074486850 @default.
- W2076715293 cites W2074706442 @default.
- W2076715293 cites W2075712201 @default.
- W2076715293 cites W2078540617 @default.
- W2076715293 cites W2080229649 @default.
- W2076715293 cites W2082865005 @default.
- W2076715293 cites W2086169454 @default.
- W2076715293 cites W2087511197 @default.