FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076724360> ?p ?o ?g. }

• W2076724360 endingPage "304" @default.
• W2076724360 startingPage "297" @default.
• W2076724360 abstract "Neurologic deficits after the surgical repair of thoracic and thoracoabdominal aortic disease are devastating complications. Recently, pharmacologic preconditioning with potassium channel openers was reported to protect the spinal cord against neurologic injury in a model of spinal cord ischemia. A novel benzopyran derivative with an N-cyanoguanidine group, KR-31378, has been synthesized as a new therapeutic agent against ischemic injury. In the present study, we evaluated the protective effects of KR-31378 on spinal cord ischemic injury and compared its neuroprotective activities and hemodynamic stabilities with those of diazoxide. Thirty-four New Zealand white rabbits were randomly divided into four groups: ischemia group (n = 10, 25 min of aortic cross-clamping without any intervention), diazoxide group (n = 8, diazoxide [5 mg/kg] intravenously 15 min before the 25-min cross-clamping), KR20 group (n = 8, KR-31378 [20 mg/kg] intravenously 30 min before the 25-min cross-clamping), and the KR50 group (n = 8, KR-31378 [50 mg/kg] intravenously 30 min before the 25-min cross-clamping). Neurologic functions were evaluated for 72 h postoperatively using modified Tarlov's scores. All rabbits were sacrificed for histopathologic observations after finally scoring neurologic function. All rabbits but three survived. The rest were completely evaluated 72 h postoperatively. Unlike diazoxide-treated rabbits, KR-31378-treated rabbits showed relatively stable hemodynamics. Tarlov's score outcomes showed a marked improvement in the diazoxide group, in the KR20 group, and in the KR50 group compared to the ischemia group (p = .005, .002, and .001, respectively). However, Tarlov's scores in the KR50 group were not significantly different from those of the diazoxide group. Histopathologic data were not significantly different between the groups, but the degree of degenerative change in motor neurons showed a significant correlation with Tarlov's scores 3 days postoperatively (gamma = -.378, p = .036). Thus, the administration of KR-31378 before the aortic cross-clamping resulted in a significant improvement in neurologic outcome with stable hemodynamics in this rabbit model." @default.
• W2076724360 created "2016-06-24" @default.
• W2076724360 creator A5007158625 @default.
• W2076724360 creator A5016844009 @default.
• W2076724360 creator A5064397663 @default.
• W2076724360 creator A5079121280 @default.
• W2076724360 date "2005-01-01" @default.
• W2076724360 modified "2023-09-24" @default.
• W2076724360 title "Neuroprotective Effect of KR-31378, a Novel Potassium Channel Activator, on Spinal Cord Ischemic Injury in Rabbits" @default.
• W2076724360 cites W1937991361 @default.
• W2076724360 cites W1973092981 @default.
• W2076724360 cites W1976033252 @default.
• W2076724360 cites W1978052737 @default.
• W2076724360 cites W2006430022 @default.
• W2076724360 cites W2018611729 @default.
• W2076724360 cites W2041189648 @default.
• W2076724360 cites W2045201746 @default.
• W2076724360 cites W2046354381 @default.
• W2076724360 cites W2047908358 @default.
• W2076724360 cites W2050147611 @default.
• W2076724360 cites W2055058686 @default.
• W2076724360 cites W2057617701 @default.
• W2076724360 cites W2058355546 @default.
• W2076724360 cites W2062978435 @default.
• W2076724360 cites W2070497696 @default.
• W2076724360 cites W2088595348 @default.
• W2076724360 cites W2095984188 @default.
• W2076724360 cites W2101892178 @default.
• W2076724360 cites W2106120652 @default.
• W2076724360 cites W2116942736 @default.
• W2076724360 cites W2121962823 @default.
• W2076724360 cites W2126937110 @default.
• W2076724360 cites W2133726443 @default.
• W2076724360 cites W2146217294 @default.
• W2076724360 cites W2160641151 @default.
• W2076724360 doi "https://doi.org/10.1080/08941930500328219" @default.
• W2076724360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16319050" @default.
• W2076724360 hasPublicationYear "2005" @default.
• W2076724360 type Work @default.
• W2076724360 sameAs 2076724360 @default.
• W2076724360 citedByCount "2" @default.
• W2076724360 crossrefType "journal-article" @default.
• W2076724360 hasAuthorship W2076724360A5007158625 @default.
• W2076724360 hasAuthorship W2076724360A5016844009 @default.
• W2076724360 hasAuthorship W2076724360A5064397663 @default.
• W2076724360 hasAuthorship W2076724360A5079121280 @default.
• W2076724360 hasConcept C118552586 @default.
• W2076724360 hasConcept C126322002 @default.
• W2076724360 hasConcept C141071460 @default.
• W2076724360 hasConcept C178853913 @default.
• W2076724360 hasConcept C25498285 @default.
• W2076724360 hasConcept C2777194220 @default.
• W2076724360 hasConcept C2778334475 @default.
• W2076724360 hasConcept C2779306644 @default.
• W2076724360 hasConcept C2779872217 @default.
• W2076724360 hasConcept C2780775167 @default.
• W2076724360 hasConcept C42219234 @default.
• W2076724360 hasConcept C44575665 @default.
• W2076724360 hasConcept C541997718 @default.
• W2076724360 hasConcept C71924100 @default.
• W2076724360 hasConcept C83743174 @default.
• W2076724360 hasConceptScore W2076724360C118552586 @default.
• W2076724360 hasConceptScore W2076724360C126322002 @default.
• W2076724360 hasConceptScore W2076724360C141071460 @default.
• W2076724360 hasConceptScore W2076724360C178853913 @default.
• W2076724360 hasConceptScore W2076724360C25498285 @default.
• W2076724360 hasConceptScore W2076724360C2777194220 @default.
• W2076724360 hasConceptScore W2076724360C2778334475 @default.
• W2076724360 hasConceptScore W2076724360C2779306644 @default.
• W2076724360 hasConceptScore W2076724360C2779872217 @default.
• W2076724360 hasConceptScore W2076724360C2780775167 @default.
• W2076724360 hasConceptScore W2076724360C42219234 @default.
• W2076724360 hasConceptScore W2076724360C44575665 @default.
• W2076724360 hasConceptScore W2076724360C541997718 @default.
• W2076724360 hasConceptScore W2076724360C71924100 @default.
• W2076724360 hasConceptScore W2076724360C83743174 @default.
• W2076724360 hasIssue "6" @default.
• W2076724360 hasLocation W20767243601 @default.
• W2076724360 hasLocation W20767243602 @default.
• W2076724360 hasOpenAccess W2076724360 @default.
• W2076724360 hasPrimaryLocation W20767243601 @default.
• W2076724360 hasRelatedWork W1967825966 @default.
• W2076724360 hasRelatedWork W2005022924 @default.
• W2076724360 hasRelatedWork W2023078460 @default.
• W2076724360 hasRelatedWork W2043111121 @default.
• W2076724360 hasRelatedWork W2094992458 @default.
• W2076724360 hasRelatedWork W2349691889 @default.
• W2076724360 hasRelatedWork W2361660271 @default.
• W2076724360 hasRelatedWork W2362571002 @default.
• W2076724360 hasRelatedWork W3148289752 @default.
• W2076724360 hasRelatedWork W3176869057 @default.
• W2076724360 hasVolume "18" @default.
• W2076724360 isParatext "false" @default.
• W2076724360 isRetracted "false" @default.
• W2076724360 magId "2076724360" @default.
• W2076724360 workType "article" @default.