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- W2076731582 abstract "An appropriate choice of the modeling formalism from the broad range of existing ones may be crucial for efficiently describing and analyzing biological systems. We propose a new unifying and incremental formalism for the representation and modeling of biological interaction networks. This formalism allows automated translations into other formalisms, thus enabling a thorough study of the dynamic properties of a biological system. As a first illustration, we propose a translation into the R. Thomas' multivalued logical formalism which provides a possible semantics; a methodology for constructing such models is presented on a classical benchmark: the λ phage genetic switch. We also show how to extract from our model a classical ODE description of the dynamics of a system. This approach provides an additional level of description between the biological and mathematical ones. It yields, on the one hand, a knowledge expression in a form which is intuitive for biologists and, on the other hand, its representation in a formal and structured way." @default.
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- W2076731582 date "2007-11-08" @default.
- W2076731582 modified "2023-10-09" @default.
- W2076731582 title "Incremental and unifying modelling formalism for biological interaction networks" @default.
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- W2076731582 doi "https://doi.org/10.1186/1471-2105-8-433" @default.
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