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• W2076732039 abstract "Beneficial effects of intravenous immunoglobulin (IVIg) in relapsing-remitting multiple sclerosis (MS) have been described, including a decrease of brain atrophy. We have previously shown that activated T cells kill neurons in culture. In this manuscript, we show that the pretreatment of activated T cells with IVIg attenuates T cell neurotoxicity. This is attributed to the ability of IVIg to decrease the adhesion of T cells onto neurons, possibly through an effect on LFA-1, and by lowering the levels of Fas and FasL on T cells. Our results are relevant to understanding how therapies affect the MS disease process." @default.
• W2076732039 created "2016-06-24" @default.
• W2076732039 creator A5069290849 @default.
• W2076732039 creator A5079991612 @default.
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• W2076732039 date "2006-08-01" @default.
• W2076732039 modified "2023-10-18" @default.
• W2076732039 title "IVIg attenuates T cell-mediated killing of human neurons" @default.
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• W2076732039 doi "https://doi.org/10.1016/j.jneuroim.2006.04.023" @default.
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