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- W2076747129 abstract "OBJECTIVE This project studies the use of airway stents coated with a cross-linked derivative of hyaluronan (HA) in a rabbit airway model of subglottic stenosis (SGS). STUDY DESIGN AND SETTING An acute subglottic mucosal injury and airway stent placement design were used in a rabbit model. Thirty-six rabbits were randomized to 6 different study groups. Four groups had the subglottic mucosa denuded at the cricoid, and 2 groups received no injury. Airway stents coated with Carbylan-SX, a cross-linked derivative of HA, and controls were placed for 3 weeks. After sacrifice at 6 weeks, morphometric measurements of subglottic lumen were taken. RESULTS In posttraumatic models, no significant differences were seen in airway area measures between groups (P = 0.86). In non-injury groups, a significant difference between Carbylan-SX versus non—HA-derivative-coated stents was seen (P = 0.05). CONCLUSION In this model of acute subglottic mucosal injury, the HA-derivative—coated stent did not improve healing. However, in the absence of mucosal injury, the Carbylan-SX film—coated stent yielded significantly larger airway areas compared with a noncoated stent. SIGNIFICANCE Stents or endotracheal tubes coated with a cross-linked derivative of HA may prevent stenosis in patients without airway injury but require long-term intubation or laryngotracheal stenting." @default.
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- W2076747129 date "2006-07-01" @default.
- W2076747129 modified "2023-09-23" @default.
- W2076747129 title "Cross‐Linked Hyaluronan‐Coated Stents in the Prevention of Airway Stenosis" @default.
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- W2076747129 doi "https://doi.org/10.1016/j.otohns.2006.01.018" @default.
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